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Aldolase A Accelerates Cancer Progression by Modulating mRNA Translation and Protein Biosynthesis via Noncanonical Mechanisms [PDF]
Advanced Science, 2023 Aldolase A (ALDOA), a crucial glycolytic enzyme, is often aberrantly expressed in various types of cancer. Although ALDOA has been reported to play additional roles beyond its conventional enzymatic role, its nonmetabolic function and underlying ...
Junjiao Song +9 more
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Protein biosynthesis in mitochondria [PDF]
Biochemistry (Moscow), 2013 Translation, that is biosynthesis of polypeptides in accordance with information encoded in the genome, is one of the most important processes in the living cell, and it has been in the spotlight of international research for many years. The mechanisms of protein biosynthesis in bacteria and in the eukaryotic cytoplasm are now understood in great ...
Kuzmenko +13 more
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Pathway and protein engineering for biosynthesis
Synthetic and Systems Biotechnology, 2022 Sustainable biosynthesis of chemicals and efforts to create new molecules of interest require efficient enzymes and pathways as well as comprehensive tools and technologies to implement this rewiring. Enzymes are the key components for construction of efficient biosynthetic pathways, enzyme characterization and engineering can help to identify key ...
Yongjin Zhou +2 more
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Mechanism of protein biosynthesis [PDF]
Bacteriological Reviews, 1969 Péter Lengyel, Dieter Söll
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Frontiers in Pharmacology, 2021 Missense mutations in the gene that encodes for the mechanically-gated ion channel Piezo1 have been linked to a number of diseases. Gain-of-function variants are linked to a hereditary anaemia and loss-of-function variants have been linked to generalized
Zijing Zhou +5 more
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Current Issues in Molecular Biology, 2022 We hypothesized that the general control nonderepressible 2 (GCN2)/eukaryotic initiation factor 2 (eIF2) signaling pathway and intracellular protein synthesis (PS) are regulated to maintain milk PS in primary bovine mammary epithelial cells (MECs) under ...
Zulma Tatiana Ruiz-Cortés +2 more
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Cryoprotective agents affect amino acids incorporation into total proteins in cells of lymphoid organs and liver of experimental animals [PDF]
The Ukrainian Biochemical Journal, 2020 The effect of penetrating (glycerol, DMSO) and poorly penetrating (PEG-400) cryoprotective agents on labeled amino acids incorporation into de novo synthesized proteins in the cells of mice thymus, lymph nodes, spleen and cell-free rat liver extract was ...
A. K. Gulevskyy +2 more
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Microorganisms, 2021 Vascular reactive oxygen species (ROS) play an essential role in cardiovascular diseases and the antioxidative effects of probiotics have been widely reported.
Yusheng Wang +7 more
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Molecules, 2021 With the relentless development of drug resistance and re-emergence of many pathogenic bacteria, the need for new antibiotics and new antibiotic targets is urgent and growing. Bacterial peptidyl-tRNA hydrolase, Pth1, is emerging as a promising new target
D. Scott Strange +6 more
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