Results 1 to 10 of about 6,137,328 (261)

Aldolase A Accelerates Cancer Progression by Modulating mRNA Translation and Protein Biosynthesis via Noncanonical Mechanisms

Advanced Science, 2023
Aldolase A (ALDOA), a crucial glycolytic enzyme, is often aberrantly expressed in various types of cancer. Although ALDOA has been reported to play additional roles beyond its conventional enzymatic role, its nonmetabolic function and underlying ...
Junjiao Song, Hongquan Li, Yanfang Liu, Xinrong Li, Qili Shi, Q. Lei, Weiguo Hu, Shenglin Huang, Zhiao Chen, Xianghuo He   +9 more
semanticscholar   +2 more sources

Down-regulation of the bacterial protein biosynthesis machinery in response to weeks, years, and decades of soil warming

Science Advances, 2022
How soil microorganisms respond to global warming is key to infer future soil-climate feedbacks, yet poorly understood. Here, we applied metatranscriptomics to investigate microbial physiological responses to medium-term (8 years) and long-term (>50 ...
Andrea Söllinger, Joana Séneca, Mathilde Borg Dahl, L. Motleleng, J. Prommer, E. Verbruggen, B. Sigurdsson, I. Janssens, J. Peñuelas, T. Urich, Andreas Richter, A. Tveit   +11 more
semanticscholar   +1 more source

SMAD4 Loss Induces c-MYC–Mediated NLE1 Upregulation to Support Protein Biosynthesis, Colorectal Cancer Growth, and Metastasis

Cancer Research, 2022
NLE1 limits de novo protein biosynthesis and the tumorigenic potential of advanced colorectal cancer cells, suggesting NLE1 could be targeted to improve the treatment of metastatic colorectal cancer.
Leon P Loevenich, Markus Tschurtschenthaler, Matjaž Rokavec, Miguel G Silva, M. Jesinghaus, T. Kirchner, Frederick Klauschen, D. Saur, J. Neumann, H. Hermeking, Peter Jung   +10 more
semanticscholar   +1 more source

Emerging connections between small RNAs and phytohormones [PDF]

, 2020
Small RNAs (sRNAs), mainly including miRNAs and siRNAs, are ubiquitous in eukaryotes. sRNAs mostly negatively regulate gene expression via (post-)transcriptional gene silencing through DNA methylation, mRNA cleavage, or translation inhibition.
Dubois, Marieke, Gonzalez Sanchez, Nathalie, Inzé, Dirk, Li, Ting   +3 more
core   +2 more sources

Three Decades of Advances in Arabinogalactan-Protein Biosynthesis

Frontiers in Plant Science, 2020
Arabinogalactan-proteins (AGPs) are a large, complex, and highly diverse class of heavily glycosylated proteins that belong to the family of cell wall hydroxyproline-rich glycoproteins.
Jessy Silva, R. Ferraz, P. Dupree, A. Showalter, S. Coimbra   +4 more
semanticscholar   +1 more source

The Streptomyces coelicolor small ORF trpM stimulates growth and morphological development and exerts opposite effects on actinorhodin and calcium-dependent antibiotic production [PDF]

, 2020
In actinomycetes, antibiotic production is often associated with a morpho-physiological differentiation program that is regulated by complex molecular and metabolic networks. Many aspects of these regulatory circuits have been already elucidated and many
Alberto Vassallo, Andrea Scaloni, Anna Maria Puglia, Emilia Palazzotto, Giovanni Renzone, Giuseppe Gallo, Luigi Botta, Teresa Faddetta   +7 more
core   +2 more sources

The Janthinobacterium sp. HH01 genome encodes a homologue of the V. cholerae CqsA and L. pneumophila LqsA autoinducer synthases [PDF]

, 2013
Janthinobacteria commonly form biofilms on eukaryotic hosts and are known to synthesize antibacterial and antifungal compounds. Janthinobacterium sp. HH01 was recently isolated from an aquatic environment and its genome sequence was established.
Blokesch, Melanie, Bode, Edna, Bode, Helge Björn, Bonge, Andreas, Daniel, Rolf, Dierking, Katja, Haack, Frederike Svenja, Hornung, Claudia, Jung, Kirsten, Krohn-Molt, Ines, Plener, Laure, Poehlein, Anja, Pohlen, Andrea, Pommerening-Röser, Andreas, Schmeißer, Christel, Schmidt, Martina, Schulenburg, Hinrich, Spieck, Eva, Streit, Wolfgang R., Timmermann, Gabriele, Utpatel, Christian   +20 more
core   +17 more sources

Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. [PDF]

, 2016
Mutations in human CLC-1 chloride channel are associated with the skeletal muscle disorder myotonia congenita. The disease-causing mutant A531V manifests enhanced proteasomal degradation of CLC-1.
Chen, Shu-Ching, Chen, Tsung-Yu, Hsieh, Hsin-Ying, Huang, Jing-Jia, Peng, Yi-Jheng, Tang, Chih-Yung, Wu, Chia-Ying, Wu, Hao-Han   +7 more
core   +1 more source

Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor [PDF]

, 2010
Background The transition from exponential to stationary phase in Streptomyces coelicolor is accompanied by a major metabolic switch and results in a strong activation of secondary metabolism.
Alam, Mohammad T., Breitling, Rainer, HASH(0x55aa09327868), Hodgson, D. A., Merlo, Maria E., Takano, Eriko, Wellington, E. M. H.   +6 more
core   +9 more sources

Biosynthesis of thiocarboxylic acid-containing natural products. [PDF]

, 2018
Thiocarboxylic acid-containing natural products are rare and their biosynthesis and biological significance remain unknown. Thioplatensimycin (thioPTM) and thioplatencin (thioPTN), thiocarboxylic acid congeners of the antibacterial natural products ...
Deng, Youchao, Dong, Liao-Bin, Duan, Yanwen, He, Cyndi Qixin, Houk, KN, Huang, Yong, Kang, Dingding, Rudolf, Jeffrey D, Shen, Ben, Wang, Nan   +9 more
core   +1 more source