Results 1 to 10 of about 438,985 (169)

Aldolase A Accelerates Cancer Progression by Modulating mRNA Translation and Protein Biosynthesis via Noncanonical Mechanisms [PDF]

Advanced Science, 2023
Aldolase A (ALDOA), a crucial glycolytic enzyme, is often aberrantly expressed in various types of cancer. Although ALDOA has been reported to play additional roles beyond its conventional enzymatic role, its nonmetabolic function and underlying ...
Junjiao Song, Hongquan Li, Yanfang Liu, Xinrong Li, Qili Shi, Qun‐Ying Lei, Weiguo Hu, Shenglin Huang, Zhiao Chen, Xianghuo He   +9 more
doaj   +2 more sources

Deoxynivalenol Affects Cell Metabolism and Increases Protein Biosynthesis in Intestinal Porcine Epithelial Cells (IPEC-J2): DON Increases Protein Biosynthesis [PDF]

Toxins, 2018
Deoxynivalenol (DON) is a toxin found in cereals as well as in processed products such as pasta, and causes substantial economic losses for stock breeding as it induces vomiting, reduced feeding, and reduced growth rates in piglets.
Constanze Nossol, Peter Landgraf, Stefan Kahlert, Michael Oster, Berend Isermann, Daniela C. Dieterich, Klaus Wimmers, Sven Dänicke, Hermann-Josef Rothkötter   +8 more
doaj   +2 more sources

Ribosome Pool Engineering Increases Protein Biosynthesis Yields [PDF]

ACS Central Science
Camila Kofman, Jessica A. Willi, Ashty S. Karim, Michael C. Jewett   +3 more
doaj   +2 more sources

Loss-of-Function Piezo1 Mutations Display Altered Stability Driven by Ubiquitination and Proteasomal Degradation

Frontiers in Pharmacology, 2021
Missense mutations in the gene that encodes for the mechanically-gated ion channel Piezo1 have been linked to a number of diseases. Gain-of-function variants are linked to a hereditary anaemia and loss-of-function variants have been linked to generalized
Zijing Zhou, Jinyuan Vero Li, Boris Martinac, Boris Martinac, Charles D. Cox, Charles D. Cox   +5 more
doaj   +1 more source

Effects of Essential Amino Acid Deficiency on General Control Nonderepressible 2/Eukaryotic Initiation Factor 2 Signaling and Proteomic Changes in Primary Bovine Mammary Epithelial Cells

Current Issues in Molecular Biology, 2022
We hypothesized that the general control nonderepressible 2 (GCN2)/eukaryotic initiation factor 2 (eIF2) signaling pathway and intracellular protein synthesis (PS) are regulated to maintain milk PS in primary bovine mammary epithelial cells (MECs) under ...
Zulma Tatiana Ruiz-Cortés, Peter Yoder, Mark D. Hanigan   +2 more
doaj   +1 more source

Cryoprotective agents affect amino acids incorporation into total proteins in cells of lymphoid organs and liver of experimental animals [PDF]

The Ukrainian Biochemical Journal, 2020
The effect of penetrating (glycerol, DMSO) and poorly penetrating (PEG-400) cryoprotective agents on labeled amino acids incorporation into de novo synthesized proteins in the cells of mice thymus, lymph nodes, spleen and cell-free rat liver extract was ...
A. K. Gulevskyy, Yu. S. Akhatova, A. Yu. Nikolchenko   +2 more
doaj   +1 more source

Supernatants of Bifidobacterium longum and Lactobacillus plantarum Strains Exhibited Antioxidative Effects on A7R5 Cells

Microorganisms, 2021
Vascular reactive oxygen species (ROS) play an essential role in cardiovascular diseases and the antioxidative effects of probiotics have been widely reported.
Yusheng Wang, Zhifeng Fang, Qixiao Zhai, Shumao Cui, Jianxin Zhao, Hao Zhang, Wei Chen, Wenwei Lu   +7 more
doaj   +1 more source

Natural Product Inhibition and Enzyme Kinetics Related to Phylogenetic Characterization for Bacterial Peptidyl-tRNA Hydrolase 1

Molecules, 2021
With the relentless development of drug resistance and re-emergence of many pathogenic bacteria, the need for new antibiotics and new antibiotic targets is urgent and growing. Bacterial peptidyl-tRNA hydrolase, Pth1, is emerging as a promising new target
D. Scott Strange, Steven S. Gaffin, W. Blake Holloway, Meredyth D. Kinsella, Jacob N. Wisotsky, Hana McFeeters, Robert L. McFeeters   +6 more
doaj   +1 more source

Recombinant HNP-1 Produced by Escherichia coli Triggers Bacterial Apoptosis and Exhibits Antibacterial Activity against Drug-Resistant Bacteria

Microbiology Spectrum, 2022
Human neutrophil peptide-1 (HNP-1) is a promising antibiotic candidate, but its clinical applications have been hampered by challenges during mass production and an inadequate understanding of its bactericidal mechanisms.
Qi Xie, Yin Wang, Mengmeng Zhang, Shujia Wu, Wei Wei, Weidi Xiao, Yihao Wang, Jinchao Zhao, Nan Liu, Yiguang Jin, Junzhu Wu, Ping Xu   +11 more
doaj   +1 more source

New Chloramphenicol Derivatives from the Viewpoint of Anticancer and Antimicrobial Activity

Antibiotics, 2019
Over the last years, we have been focused on chloramphenicol conjugates that combine in their structure chloramphenicol base with natural polyamines, spermine, spermidine and putrescine, and their modifications.
Panagiota C. Giannopoulou, Dionissia A. Missiri, Georgia G. Kournoutou, Eleni Sazakli, Georgios E. Papadopoulos, Dionissios Papaioannou, George P. Dinos, Constantinos M. Athanassopoulos, Dimitrios L. Kalpaxis   +8 more
doaj   +1 more source