Results 11 to 20 of about 847,691 (346)

Natural Product Inhibition and Enzyme Kinetics Related to Phylogenetic Characterization for Bacterial Peptidyl-tRNA Hydrolase 1

Molecules, 2021
With the relentless development of drug resistance and re-emergence of many pathogenic bacteria, the need for new antibiotics and new antibiotic targets is urgent and growing. Bacterial peptidyl-tRNA hydrolase, Pth1, is emerging as a promising new target
D. Scott Strange, Steven S. Gaffin, W. Blake Holloway, Meredyth D. Kinsella, Jacob N. Wisotsky, Hana McFeeters, Robert L. McFeeters   +6 more
doaj   +1 more source

Recombinant HNP-1 Produced by Escherichia coli Triggers Bacterial Apoptosis and Exhibits Antibacterial Activity against Drug-Resistant Bacteria

Microbiology Spectrum, 2022
Human neutrophil peptide-1 (HNP-1) is a promising antibiotic candidate, but its clinical applications have been hampered by challenges during mass production and an inadequate understanding of its bactericidal mechanisms.
Qi Xie, Yin Wang, Mengmeng Zhang, Shujia Wu, Wei Wei, Weidi Xiao, Yihao Wang, Jinchao Zhao, Nan Liu, Yiguang Jin, Junzhu Wu, Ping Xu   +11 more
doaj   +1 more source

Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. [PDF]

, 2016
Mutations in human CLC-1 chloride channel are associated with the skeletal muscle disorder myotonia congenita. The disease-causing mutant A531V manifests enhanced proteasomal degradation of CLC-1.
Chen, Shu-Ching, Chen, Tsung-Yu, Hsieh, Hsin-Ying, Huang, Jing-Jia, Peng, Yi-Jheng, Tang, Chih-Yung, Wu, Chia-Ying, Wu, Hao-Han   +7 more
core   +1 more source

FabR regulates Salmonella biofilm formation via its direct target FabB [PDF]

, 2016
Background: Biofilm formation is an important survival strategy of Salmonella in all environments. By mutant screening, we showed a knock-out mutant of fabR, encoding a repressor of unsaturated fatty acid biosynthesis (UFA), to have impaired biofilm ...
De Coster, David, De Keersmaecker, Sigrid CJ, Hermans, Kim, Kint, Gwendoline, Marchal, Kathleen, Roberfroid, Stefanie, Steenackers, Hans P, Thijs, Inge M, Vanderleyden, Jos   +8 more
core   +4 more sources

New Chloramphenicol Derivatives from the Viewpoint of Anticancer and Antimicrobial Activity

Antibiotics, 2019
Over the last years, we have been focused on chloramphenicol conjugates that combine in their structure chloramphenicol base with natural polyamines, spermine, spermidine and putrescine, and their modifications.
Panagiota C. Giannopoulou, Dionissia A. Missiri, Georgia G. Kournoutou, Eleni Sazakli, Georgios E. Papadopoulos, Dionissios Papaioannou, George P. Dinos, Constantinos M. Athanassopoulos, Dimitrios L. Kalpaxis   +8 more
doaj   +1 more source

Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor [PDF]

, 2010
Background The transition from exponential to stationary phase in Streptomyces coelicolor is accompanied by a major metabolic switch and results in a strong activation of secondary metabolism.
Alam, Mohammad T., Breitling, Rainer, HASH(0x55aa09327868), Hodgson, D. A., Merlo, Maria E., Takano, Eriko, Wellington, E. M. H.   +6 more
core   +10 more sources

Transimulation - protein biosynthesis web service. [PDF]

PLoS ONE, 2013
Although translation is the key step during gene expression, it remains poorly characterized at the level of individual genes. For this reason, we developed Transimulation - a web service measuring translational activity of genes in three model organisms:
Marlena Siwiak, Piotr Zielenkiewicz
doaj   +1 more source

Group V Phospholipase A2 Induces Leukotriene Biosynthesis in Human Neutrophils through the Activation of Group IVA Phospholipase A2 [PDF]

, 2002
We reported previously that exogenously added human group V phospholipase A2 (hVPLA2) could elicit leukotriene B4 (LTB4) biosynthesis in human neutrophils (Han, S. K., Kim, K. P., Koduri, R., Bittova, L., Munoz, N. M., Leff, A. R., Wilton, D. C., Gelb, M.
Cho, Wonhwa, Han, Sang Kyou, Kim, Kwang Pyo, Kim, Young Jun, Leff, Alan R., Munoz, Nilda M., Sano, Hiroyuki, Zhu, Xiangdong   +7 more
core   +1 more source

Elucidation of transient protein-protein interactions within carrier protein-dependent biosynthesis

Communications Biology, 2021
Using structural and computational analysis, Bartholow et al. perform a comprehensive residue-by-residue comparison of the protein-protein interactions in de novo fatty acid biosynthesis that occurs in E. coli. This study provides insights into molecular
Thomas G. Bartholow, Terra Sztain, Ashay Patel, D. John Lee, Megan A. Young, Ruben Abagyan, Michael D. Burkart   +6 more
doaj   +1 more source

Toward eradication of B-vitamin deficiencies : considerations for crop biofortification [PDF]

, 2018
'Hidden hunger' involves insufficient intake of micronutrients and is estimated to affect over two billion people on a global scale. Malnutrition of vitamins and minerals is known to cause an alarming number of casualties, even in the developed world ...
Strobbe, Simon, Van Der Straeten, Dominique   +1 more
core   +3 more sources