Results 191 to 200 of about 820,747 (349)

Reprogramming of Fatty Acid Metabolism via PPARα‐Orchestrated FADS2 in Keratinocytes Modulates Skin Inflammation in Psoriasis

Advanced Science, EarlyView.
This study identifies fatty acid desaturase 2 (FADS2) as a key regulator linking polyunsaturated fatty acid (PUFA) metabolism to psoriatic inflammation. FADS2 deficiency impairs docosahexaenoic acid (DHA) biosynthesis, enhances NF‐κB signaling, and promotes neutrophil‐driven skin inflammation. PPARα transcriptionally activates FADS2, and its activation
Jiangluyi Cai, Xue Zhou, Yu Zhuang, Lian Cui, Rui Ma, Youdong Chen, Nan Yang, Qianyu Chen, Yuanyuan Wang, Peiyao Zhu, Lingling Yao, Qian Yu, Xiaomin She, Xuyang Zhou, Yuemeng Huang, Zengyang Yu, Xilin Zhang, Jiajing Lu, Yuling Shi, Chunyuan Guo   +19 more
wiley   +1 more source

Thioesters Support Efficient Protein Biosynthesis by the Ribosome. [PDF]

ACS Cent Sci
Kent AD, Robins JG, Knudson IJ, Vance JT, Solivan AC, Hamlish NX, Fitzgerald KA, Schepartz A, Miller SJ, Cate JHD.   +9 more
europepmc   +1 more source

Three Decades of Advances in Arabinogalactan-Protein Biosynthesis. [PDF]

Front Plant Sci, 2020
Silva J, Ferraz R, Dupree P, Showalter AM, Coimbra S.   +4 more
europepmc   +1 more source

Quantitative proteomic analyses reveal that energy metabolism and protein biosynthesis reinitiation are responsible for the initiation of bolting induced by high temperature in lettuce (Lactuca sativa L.). [PDF]

BMC Genomics, 2021
Hao JH, Su HN, Zhang LL, Liu CJ, Han YY, Qin XX, Fan SX.   +6 more
europepmc   +1 more source

Skullcapflavone II Inhibits SLC1A4‐Mediated L‐Serine Uptake and Promotes Mitochondrial Damage in Gastric Cancer

Advanced Science, EarlyView.
Skullcapflavone II (SkII) significantly alters serine metabolism in gastric cancer cells by directly targeting the L‐serine transporter SLC1A4, thereby inhibiting L‐serine uptake rather than de novo synthesis. This disruption of serine metabolism by SkII leads to increased oxidative stress and consequent mitochondrial damage.
Jing Zhao, Yu‐Bo Ma, Rui‐Hong Xia, Zheng‐Chen Jiang, Ying Zhou, Ya‐Nan Wang, Meng‐Yan Yang, Jing‐Jie Dai, Tao Zhu, Li‐Bin Pan, Li Yuan   +10 more
wiley   +1 more source

OsGATA7 and SMOS1 cooperatively determine rice taste quality by repressing OsGluA2 expression and protein biosynthesis. [PDF]

Nat Commun
Cao N, Zhou W, Zhao F, Jiao G, Xie L, Lu A, Wu J, Zhu M, Liu Y, Yu J, Zhao R, Yang X, Hu S, Sheng Z, Wei X, Lv Y, Tang S, Shao G, Hu P.   +18 more
europepmc   +1 more source

Inhibition and Stimulation of the Biosynthesis of Protein and Nucleic Acid. II. Inhibition Sites of 4-Fluoro- and 4-Nitro-phenylalanines on the Incorporation of Phenylalanine into Proteins of Ehrlich Mouse Ascites Tumor Cells in vitro

, 1968
Osamu Tamemasa, Shoji Okada, Setsuo IWASAKI, Eiko Watanabe   +3 more
openalex   +2 more sources

A Mass Spectrometry Approach Reveals Fatty Acid Isomerism in Tomato Cold Tolerance

Advanced Science, EarlyView.
An enhanced mass spectrometry approach reveals fatty acids (FAs) and FA isomers that are critical for tomato cold tolerance. Applying specific FA isomers can partially rescue cold sensitivity in tomato mutant plants, highlighting the importance of FA isomers in plant cold stress adaptation.
Leelyn Chong, Hengxue Shi, Qirui Yu, Xiaoning Shi, Zhaoxing Jia, Ziyun Dong, Yu Xia, Yingfang Zhu   +7 more
wiley   +1 more source

Protein Biosynthesis and Carbon Catabolite Repression Are Transcriptionally Upregulated in Saccharomyces cerevisiae by Extracellular Fractions From Several Wine Yeast Species. [PDF]

Microb Biotechnol
Mejias-Ortiz M, Morales P, Juárez G, Gonzalez R.   +3 more
europepmc   +1 more source

Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic‐Induced Transformation

Advanced Science, EarlyView.
Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang, Zhuoyue Bi, Jessica Bamrah, Yiran Qiu, Wenxuan Zhang, Bandar Saeed Almutairy, Haoyan Ji, John D. Haley, Chitra Thakur, Fei Chen   +9 more
wiley   +1 more source