Results 61 to 70 of about 4,061,795 (267)
PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation [PDF]
, 2014 Arsenic is a clinically effective treatment for acute promyelocytic leukaemia (APL) in which the promyelocytic leukaemia (PML) protein is fused to retinoic receptor alpha (RARα).
Hands, K.J. +7 more
core +1 more source
Cell Reports, 2018 Summary: Aging is accompanied by a pervasive collapse of proteostasis, while reducing general protein synthesis promotes longevity across taxa. Here, we show that the eIF4E isoform IFE-2 is increasingly sequestered in mRNA processing (P) bodies during ...
Matthias Rieckher +4 more
doaj +1 more source
A simplified method for the efficient refolding and purification of recombinant human GM-CSF. [PDF]
PLoS ONE, 2012 Human granulocyte macrophage colony-stimulating factor (hGM-CSF) is a haematopoietic growth factor and proinflammatory cytokine. Recombinant hGM-CSF is important not only as a research tool but also as a biotherapeutic.
Christy A Thomson +3 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Ataxin-1 fusion partners alter polyQ lethality and aggregation [PDF]
, 2007 Intranuclear inclusion bodies (IBs) are the histopathologic markers of multiple protein folding diseases. IB formation has been extensively studied using fluorescent fusion products of pathogenic polyglutamine (polyQ) expressing proteins.
Rich, T. +5 more
core +2 more sources
WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies. [PDF]
PLoS Biology, 2010 The WRAP53 gene gives rise to a p53 antisense transcript that regulates p53. This gene also encodes a protein that directs small Cajal body-specific RNAs to Cajal bodies.
Salah Mahmoudi +7 more
doaj +1 more source
Sex body: A nest of protein mixture
Frontiers in Cell and Developmental Biology, 2023 During the pachytene stage in mammalian meiosis, the X and Y chromosomes remain largely unsynapsed outside the pseudoautosomal region, while autosomes are fully synapsed. Then, the sex chromosomes are compartmentalized into a “sex body” in the nucleus and are subjected to meiotic sex chromosome inactivation (MSCI).
openaire +3 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural studies of protein deposition in developing legume seeds [PDF]
, 1983 A comparative study of storage protein deposition has been made in developing seeds of a range of legumes. Varieties of pisum sativum, vicia faba, vigna unguiculata, and Phaseolus vulgaris have been examined.
Bakhtiar, A.
core
Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 nuclear bodies [PDF]
, 2009 Background: Active pre-mRNA splicing occurs co-transcriptionally, and takes place throughout the nucleoplasm of eukaryotic cells. Splicing decisions are controlled by networks of nuclear RNA-binding proteins and their target sequences, sometimes in ...
Rajan, P. +55 more
core +1 more source