Results 261 to 270 of about 7,288,800 (308)
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Homozygous protein C deficiency—management with protein C concentrate
European Journal of Pediatrics, 1995Two unrelated female infants with homozygous protein C (Pr C) deficiency are reported. Both are of U.K. Pakistani origin and in each case the parents are consanguinous. A previous sibling had died in each family. Both sets of parents were shown to be carriers. The concentration of Pr C in both infants was low at birth.
V, Baliga +5 more
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Activated protein C versus protein C in severe sepsis
Critical Care Medicine, 2001To delineate critical differences between activated protein C (APC) and its precursor, protein C, with regard to plasma levels in health and in severe sepsis, and to discuss the implications of these differences as they relate to treatment strategies in patients with severe sepsis.
S B, Yan, J F, Dhainaut
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Critical Care Medicine, 2000
The protein C anticoagulant pathway serves as a major system for controlling thrombosis, limiting inflammatory responses, and potentially decreasing endothelial cell apoptosis in response to inflammatory cytokines and ischemia. The essential components of the pathway involve thrombin, thrombomodulin, the endothelial cell protein C receptor (EPCR ...
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The protein C anticoagulant pathway serves as a major system for controlling thrombosis, limiting inflammatory responses, and potentially decreasing endothelial cell apoptosis in response to inflammatory cytokines and ischemia. The essential components of the pathway involve thrombin, thrombomodulin, the endothelial cell protein C receptor (EPCR ...
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Resistance to activated protein C mimicking dysfunctional protein C
Blood Coagulation & Fibrinolysis, 1996It has been reported that resistance to activated protein C interferes with functional plasma-based coagulation assays of protein C, mimicking a type II deficiency. In this study we confirm and extend these findings. In our laboratory approximately 25% of patients with resistance to activated protein C have an apparent type II protein C deficiency.
E. Faioni +3 more
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Progress in hemostasis and thrombosis, 1985
The protein C anticoagulant pathway provides many new insights into control mechanisms for regulating coagulation. The observation that protein C deficiency is associated with thrombotic tendencies in the heterozygote (106-109) and early, lethal thrombosis in the homozygote (110, 111) points to the importance of the system as a major regulatory pathway.
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The protein C anticoagulant pathway provides many new insights into control mechanisms for regulating coagulation. The observation that protein C deficiency is associated with thrombotic tendencies in the heterozygote (106-109) and early, lethal thrombosis in the homozygote (110, 111) points to the importance of the system as a major regulatory pathway.
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Endothelial Protein C Receptor
Thrombosis and Haemostasis, 1999IntroductionThe protein C anticoagulant pathway plays a critical role in the negative regulation of the blood clotting response. The pathway is triggered by thrombin, which allows the system to serve as an “on-demand” mechanism for limiting the coagulation response to injury.
C T, Esmon +9 more
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Neurochemistry International, 1997
The protein kinase C (PKC) family of serine/threonine kinase isoenzymes are universally expressed in vertebrate tissues where they control vital cellular functioning. PKC comprises twelve currently identified mammalian isoenzymes, described in three distinct groups according to their need for different effector stimulation.
J P, Wood, R J, McCord, N N, Osborne
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The protein kinase C (PKC) family of serine/threonine kinase isoenzymes are universally expressed in vertebrate tissues where they control vital cellular functioning. PKC comprises twelve currently identified mammalian isoenzymes, described in three distinct groups according to their need for different effector stimulation.
J P, Wood, R J, McCord, N N, Osborne
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Protein Kinase C Isotypes in C. elegans
Journal of Biochemistry, 2002The protein kinase C (PKC) family, consisting of multiple isotypes, plays a major role in cellular signaling. In the nematode Caenorhabditis elegans, four pkc genes, tpa-1, pkc-1, pkc-2 and pkc-3, have been identified and investigated. Molecular analysis of tpa-1, pkc-1, and pkc-2 has shown that each gene encodes multiple PKC isoforms with different ...
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1997
Blood coagulation is a complex chain reaction of enzyme activations in which inactive zymogens are activated by proteolytic cleavage. Each newly activated enzyme in turn cleaves the next zymogen in the chain, resulting in its activation. The final enzyme in the cascade, thrombin, then cleaves soluble fibrinogen into insoluble fibrin which forms a ...
S T, Cooper, F C, Church
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Blood coagulation is a complex chain reaction of enzyme activations in which inactive zymogens are activated by proteolytic cleavage. Each newly activated enzyme in turn cleaves the next zymogen in the chain, resulting in its activation. The final enzyme in the cascade, thrombin, then cleaves soluble fibrinogen into insoluble fibrin which forms a ...
S T, Cooper, F C, Church
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