Results 261 to 270 of about 25,791,466 (309)
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Critical Care Medicine, 2000
The protein C anticoagulant pathway serves as a major system for controlling thrombosis, limiting inflammatory responses, and potentially decreasing endothelial cell apoptosis in response to inflammatory cytokines and ischemia. The essential components of the pathway involve thrombin, thrombomodulin, the endothelial cell protein C receptor (EPCR ...
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The protein C anticoagulant pathway serves as a major system for controlling thrombosis, limiting inflammatory responses, and potentially decreasing endothelial cell apoptosis in response to inflammatory cytokines and ischemia. The essential components of the pathway involve thrombin, thrombomodulin, the endothelial cell protein C receptor (EPCR ...
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Southern Medical Journal, 1987
Severe homozygous protein C deficiency is a rare but serious problem in the newborn, with a clinical presentation of purpura fulminans. We have presented such a case in an 1,870 gm female neonate. Salient clinical findings in this case include DIC associated with extensive ecchymosis and subsequent gangrene of the skin, thrombotic complications that ...
E S, Rappaport +6 more
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Severe homozygous protein C deficiency is a rare but serious problem in the newborn, with a clinical presentation of purpura fulminans. We have presented such a case in an 1,870 gm female neonate. Salient clinical findings in this case include DIC associated with extensive ecchymosis and subsequent gangrene of the skin, thrombotic complications that ...
E S, Rappaport +6 more
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A radioimmunoassay for protein C
Thrombosis Research, 1985A simple and dependable radioimmunoassay has been devised to measure protein C in human plasma. From a rabbit antiserum against human protein C, the antibodies recognizing the activation peptide region (residues 1-15) in the heavy chain of protein C were affinity purified for use in the radioimmunoassay.
K, Ikeda, J, Stenflo
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Seminars in Thrombosis and Hemostasis, 1988
With the continued accumulation of clinical and animal studies, it is becoming abundantly clear that the protein C anticoagulant pathway plays a critical role in the regulation of coagulation. Investigations also indicate that this pathway is intimately involved in the interaction of the coagulation and inflammatory systems.
N L, Esmon, C T, Esmon
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With the continued accumulation of clinical and animal studies, it is becoming abundantly clear that the protein C anticoagulant pathway plays a critical role in the regulation of coagulation. Investigations also indicate that this pathway is intimately involved in the interaction of the coagulation and inflammatory systems.
N L, Esmon, C T, Esmon
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Blood Cells, Molecules, and Diseases, 2006
Protein C, a vitamin K-dependent serine protease zymogen that circulates in plasma, is converted by limited proteolysis to activated protein C (APC) by the thrombin-thrombomodulin complex. APC exerts anticoagulant, antiinflammatory, cytoprotective, and antiapoptotic activities. Recombinant APC therapy reduces mortality in severe sepsis patients.
John H, Griffin +6 more
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Protein C, a vitamin K-dependent serine protease zymogen that circulates in plasma, is converted by limited proteolysis to activated protein C (APC) by the thrombin-thrombomodulin complex. APC exerts anticoagulant, antiinflammatory, cytoprotective, and antiapoptotic activities. Recombinant APC therapy reduces mortality in severe sepsis patients.
John H, Griffin +6 more
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Activated protein C versus protein C in severe sepsis
Critical Care Medicine, 2001To delineate critical differences between activated protein C (APC) and its precursor, protein C, with regard to plasma levels in health and in severe sepsis, and to discuss the implications of these differences as they relate to treatment strategies in patients with severe sepsis.
S B, Yan, J F, Dhainaut
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Phosphorylation of bovine cardiac C-protein by protein kinase C
Biochemical and Biophysical Research Communications, 1985C-protein, a thick filament-associated protein, has been isolated from bovine myocardium and found to be a substrate in vitro of the Ca2+- and phospholipid-dependent protein kinase (protein kinase C). Incorporation of approximately 1.6 mol Pi/mol C-protein was observed.
M S, Lim, C, Sutherland, M P, Walsh
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Proteolysis of protein C in pooled normal plasma and purified protein C by activated protein C (APC)
Biophysical Chemistry, 2002Protein C is a vitamin-K dependent zymogen of the anti-coagulant serine protease activated protein C (APC). In this paper, we report four lines of evidence that APC can activate protein C in pooled normal plasma, and purified protein C. First, the addition of APC to protein C-deficient plasma supplemented with protein C produces a prolongation of the ...
Houria, Hassouna, Christopher, Quinn
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Effect of Desmopressin (DDAVP) on Protein C and Protein C Inhibitors in Uremia
Nephron, 1993The effect of desmopressin (DDAVP) on protein C (PC) and PC inhibitors was investigated in 7 uremic predialysis patients, 7 hemodialysis patients and 7 controls. Significant decrease in PC activity was observed in all groups after DDAVP administration.
AKPOLAT, T +10 more
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Protein Kinase C Isotypes in C. elegans
Journal of Biochemistry, 2002The protein kinase C (PKC) family, consisting of multiple isotypes, plays a major role in cellular signaling. In the nematode Caenorhabditis elegans, four pkc genes, tpa-1, pkc-1, pkc-2 and pkc-3, have been identified and investigated. Molecular analysis of tpa-1, pkc-1, and pkc-2 has shown that each gene encodes multiple PKC isoforms with different ...
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