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Protein C and S Deficiency

Seminars in Thrombosis and Hemostasis, 1999
Protein C and S deficiency states predispose affected individuals to thrombosis, especially venous thrombosis of the lower extremities, usually beginning in the teenage years. Treatment of these patients is generally with oral anticoagulation, following initial heparinization.
F A, Nizzi, H S, Kaplan
exaly   +3 more sources

Asymptomatic Homozygous Protein C Deficiency

open access: yesActa Haematologica, 2009
We report a family in which 2 homozygotes with similarly very low protein C levels have different clinical symptoms. One had recurrent venous thrombosis starting at the age of 28 years, the other is still asymptomatic at 38 years despite exposure to thrombotic risk factors.
A. Tripodi   +3 more
openaire   +4 more sources

Clinical management of protein C deficiency

Expert Opinion on Pharmacotherapy, 2001
Protein C (PC) is a vitamin K-dependent plasma protein that is structurally similar to other coagulation factors such as prothrombin and Factor X. PC is converted to its active anticoagulant form by a thrombin-thrombomodulin complex on the surface of capillary endothelial cells.
exaly   +3 more sources

Protein C Deficiency

Neonatal Network, 2011
ABSTRACTProtein C (PC) deficiency is a rare but life-threatening bleeding disorder that can present in the immediate neonatal period. This article presents the case of a baby girl with acute and progressive neonatal purpura fulminans as the presenting feature of PC deficiency.
Alicia, Kelly, Gregory D, Pearson
openaire   +3 more sources

Protein C Deficiency

Southern Medical Journal, 1987
Severe homozygous protein C deficiency is a rare but serious problem in the newborn, with a clinical presentation of purpura fulminans. We have presented such a case in an 1,870 gm female neonate. Salient clinical findings in this case include DIC associated with extensive ecchymosis and subsequent gangrene of the skin, thrombotic complications that ...
E S, Rappaport   +6 more
openaire   +2 more sources

Protein C deficiency

Haemophilia, 2008
Summary.  Severe protein C deficiency (i.e. protein C activity <1 IU dL−1) is a rare autosomal recessive disorder that usually presents in the neonatal period with purpura fulminans (PF) and severe disseminated intravascular coagulation (DIC), often with concomitant venous thromboembolism (VTE).
N A, Goldenberg, M J, Manco-Johnson
openaire   +2 more sources

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