Results 161 to 170 of about 22,165,413 (298)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

From Minor Knee Laceration to Multisystem Catastrophe: A Five-Year-Old Boy's Battle With Protein C Deficiency and Purpura Fulminans. [PDF]

Cureus
Ali S, Alfalasi S, Al Nuaimi M.
europepmc   +1 more source

The c.1243T>C mutation in the PROC gene is linked with inherited protein C deficiency and severe purpura fulminans. [PDF]

Clin Case Rep, 2023
Nourbakhsh SMK, Bahadoram M, Rashidi-Nezhad A, Habibi L, Mansouri F, Akade E.   +5 more
europepmc   +1 more source

A Case Report of Protein C Deficiency in a Neonate with Purpura Fulminans and Bilateral Cataract [PDF]

Protein C is a vitamin K dependent glycoprotein. Protein C deficiency is a rare genetic disorder and its major sites of involvement are skin, eyes, lungs, central nervous system, and kidneys.
انتشاری مقدم, افسانه, احدی, عادل, میرزا رحیمی, مهرداد, براک, منوچهر   +3 more
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Congenital Protein C Deficiency Presenting as Neonatal Purpura Fulminans: A Report of Two Cases. [PDF]

Cureus
Thaddanee R, Tilwani S, Kesharani T, Shah J, Sheikh N.   +4 more
europepmc   +1 more source

Plasma proteins in vitamin C deficiency [PDF]

British Journal of Nutrition, 1958
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Management of Severe Congenital Protein C Deficiency with Continuous Subcutaneous Infusion via Insulin Pump: A Pediatric Case Report. [PDF]

Children (Basel)
Gentile A, Spacco G, Minuto N, Morsellino V, Dallorso S, Molinari AC, Maghnie M, Bassi M, Banov L.   +8 more
europepmc   +1 more source

Acute Portal Vein Thrombosis as an Initial Presentation of Protein C Deficiency: A Case Report. [PDF]

Cureus, 2023
Proskuriakova E, Jasaraj RB, Shrestha DB, Reddy VK, Khosla P.   +4 more
europepmc   +1 more source