Results 181 to 190 of about 22,165,413 (298)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Multisystem embolism in hereditary protein C deficiency with patent foramen ovale: a case report. [PDF]

Front Cardiovasc Med
Chen L, Guan J, Ni Y.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pulmonary Embolism Presenting as Recurrent Syncope and Visual Disturbances in a Patient With Protein C Deficiency: An Atypical Emergency Department Presentation. [PDF]

Cureus
Rana T, Kaeley N, Tejpal P, Yadav S, Mudi D.   +4 more
europepmc   +1 more source

Molecular basis of inherited protein C deficiency results from genetic variations in the signal peptide and propeptide regions. [PDF]

J Thromb Haemost, 2023
Cao Q, Hao Z, Li C, Chen X, Gao M, Jiang N, Liu H, Shen Y, Yang H, Zhang S, Yang A, Li W, Tie JK, Shen G.   +13 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Idiopathic pulmonary hemosiderosis and stroke secondary to protein C deficiency in a child with Down syndrome: a case report. [PDF]

J Med Case Rep, 2023
Ajmi H, Bouafsoun C, Arifa N, Chemli J, Abroug S.   +4 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Liver Transplantation as a Definitive Treatment for Homozygous Protein C Deficiency. [PDF]

Cureus
Syed Iqbaluddin J, Asif Amin S, Fawzy Nazir Abouelkhel H, Shaji Mathew J, Sen G, Saif R.   +5 more
europepmc   +1 more source

Hereditary protein C deficiency with portal vein thrombosis in a Chinese male: A case report. [PDF]

Exp Ther Med, 2022
Zou C, Li T, Long L, Liu L, Zhu J.
europepmc   +1 more source