Results 71 to 80 of about 1,141,379 (303)

Protein C or Protein S deficiency associates with paradoxically impaired platelet‐dependent thrombus and fibrin formation under flow

Research and Practice in Thrombosis and Haemostasis, 2022
Background Low plasma levels of protein C or protein S are associated with venous thromboembolism rather than myocardial infarction. The high coagulant activity in patients with thrombophilia with a (familial) defect in protein C or S is explained by ...
Sanne L. N. Brouns, Bibian M. E. Tullemans, Cristiana Bulato, Gina Perrella, Elena Campello, Luca Spiezia, Johanna P. vanGeffen, Marijke J. E. Kuijpers, René vanOerle, Henri M. H. Spronk, Paola E. J. van derMeijden, Paolo Simioni, Johan W. M. Heemskerk   +12 more
doaj   +1 more source

Atrophy, oxidative switching and ultrastructural defects in skeletal muscle of the ataxia telangiectasia mouse model [PDF]

, 2019
Ataxia telangiectasia is a rare, multi system disease caused by ATM kinase deficiency. Atm-knockout mice recapitulate premature aging, immunodeficiency, cancer predisposition, growth retardation and motor defects, but not cerebellar neurodegeneration and
Aguanno, Salvatore, Bolasco, Giulia, De Angelis, Luciana, De Gennaro, Vincenzo, Marazziti, Daniela, Naro, Fabio, Pellegrini, Manuela, Sala, Gina La, Tassinari, Valentina   +8 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Tyrosine hydroxylase deficiency: a treatable disorder of brain catecholamine biosynthesis [PDF]

, 2017
Tyrosine hydroxylase deficiency is an autosomal recessive disorder resulting from cerebral catecholamine deficiency. Tyrosine hydroxylase deficiency has been reported in fewer than 40 patients worldwide. To recapitulate all available evidence on clinical
Aeby, Alec, Blau, Nenad, Burlina, Alberto, de Klerk, Johannis B., de Lonlay, Pascale, de Rijk-van Andel, Johanneke F., Donati, Maria A., Geurtz, Ben, Grattan-Smith, Padraic J., Haeussler, Martin, Hoffmann, Georg F., Jung, Hans, Kamsteeg, Erik-Jan, Kok, Fernando, Leuzzi, Vincenzo, Megarbane, Andre, Monaghan, Hugh, Renier, Willy O., Rondot, Pierre, Ryan, Monique M., Seeger, Jürgen, Smeitink, Jan A., Steenbergen-Spanjers, Gerry C., van der Knaap, Marjo S., Verbeek, Marcel M., Wassmer, Evangeline, Weschke, Bernhard, Wevers, Ron A., Wijburg, Frits A., Wilcken, Bridget, Willemsen, Michèl A., Zafeiriou, Dimitrios I.   +31 more
core  

Toward eradication of B-vitamin deficiencies : considerations for crop biofortification [PDF]

, 2018
'Hidden hunger' involves insufficient intake of micronutrients and is estimated to affect over two billion people on a global scale. Malnutrition of vitamins and minerals is known to cause an alarming number of casualties, even in the developed world ...
Strobbe, Simon, Van Der Straeten, Dominique   +1 more
core   +3 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

The Level of C-Reactive Protein in the Blood Plasma of Young Adults with Childhood-Onset Growth Hormone Deficiency

Mìžnarodnij Endokrinologìčnij Žurnal, 2016
The article presents the data on the level of high-sensitivity C-reactive protein in the blood plasma of young adults with growth hormone deficiency that occurred in childhood and persists in adulthood.
O.V. Bolshova, T.O. Tkachova, O.A. Vyshnevska   +2 more
doaj   +1 more source

Hubungan Konsumsi Asupan Protein, Zat Besi Dan Vitamin C Dengan Kadar Hemoglobin Pada Ibu Hamil Di Desa Joho Kecamatan Mojolaban Kabupaten Sukoharjo [PDF]

, 2015
Pregnant mother is a group of persons who have high risk of anemia. Beside iron substance deficiency, anemia could happen because of others nutrient deficiency. The protein intake has a role in the iron substance transportation in a whole body.
, Dr. Mutalazimah, SKM, M.Kes, , Dwi Sarbini, S.ST., M.Kes, OKTAVIA MANDASARI, RACHMAWATI   +2 more
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source