Results 71 to 80 of about 22,165,413 (298)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Severe protein C deficiency in a newborn caused by a homozygous pathogenic variant in the PROC gene: a case report

BMC Pediatrics, 2021
Background Severe protein C deficiency is a rare and inherited cause of thrombophilia in neonates. Protein C acts as an anticoagulant, and its deficiency results in vascular thrombosis.
Uisook Song, Young Hye Ryu, Kiteak Hong, So-Yeon Shim, Seongyeol Park, Jeong Seok Lee, Young Seok Ju, Seung Han Shin, Soyoung Lee   +8 more
doaj   +1 more source

Expressed protein ligation for a large dimeric protein [PDF]

, 2011
Expressed protein ligation (EPL) is a protein engineering tool for post-translational ligation of protein or peptide fragments. This technique allows modification of specific parts of proteins, opening possibilities for incorporating probes for ...
NMR Spectroscopy, Karagöz, G.E., Sub Cellular Protein Chemistry, O. Hsieh, Sub NMR Spectroscopy, T. Sinnige, Rüdiger, S.G.D., Hsieh, O., Sinnige, T, G. E. Karagoz, S. G. D. Rudiger, Cellular Protein Chemistry   +11 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Protein C and protein S deficiency associated cerebral venous thrombosis: one case report

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To report one case with protein C deficiency (PCD) and protein S deficiency (PSD) associated cerebral venous thrombosis (CVT), and to explore diagnostic and therapeutic strategies.
HUANG Zhan, ZHU Ming-fang, MENG Qi, TAN Lei-lei, ZHANG Jie-wen, HUANG Yue   +5 more
doaj   +1 more source

Recurrent diffuse lung disease due to surfactant protein C deficiency

Respiratory Medicine Case Reports, 2018
Surfactant protein C (SP-C) deficiency causes diffuse lung disease with variable prognosis and severity that usually presents in infancy. We present the case of a patient with diffuse lung disease who was successfully treated with hydroxychloroquine and ...
Brigitte Kazzi, David Lederer, Emilio Arteaga-Solis, Anjali Saqi, Wendy K. Chung   +4 more
doaj   +1 more source

Is Treatment With Hydroxychloroquine Effective in Surfactant Protein C Deficiency?

, 2013
We present the case of two twin brothers with surfactant protein C deficiency who were treated with hydroxychloroquine for three years, with apparent success.
Poli F, VENTURA, ALESSANDRO, Rabach I, Germani C, Barbi E., Zennaro F   +5 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Stroke in an Infant; Its Association with Antiphospholipid Antibody and Acquired Protein C and S Deficiencies

Iranian Journal of Allergy, Asthma and Immunology, 2004
We present the first reported case of antiphospholipid syndrome with stroke in an Iranian boy (7-month-old) who had two ischemic strokes within a period of 2 months.
Soroor Inaloo Mohammad Ghofrani
doaj  

Clinico-Etiological Study of Purpura Fulminans: Experience from a Tertiary-Care Children Hospital

Indian Dermatology Online Journal
Background: Purpura fulminans (PF) is a potentially fatal disease characterized by rapidly progressive purpura that evolves into cutaneous necrosis and gangrene.
Shaziya Kalam, Sahana M. Srinivas, M. L. Keshavamurthy, G. V. Basavaraja, Pragalatha Kumar   +4 more
doaj   +1 more source