Results 141 to 150 of about 734,673 (317)

Effect of cavitation jet technology on instant solubility characteristics of soymilk flour: Based on the change of protein conformation in soymilk. [PDF]

Ultrason Sonochem, 2023
Gong Q, Liu C, Tian Y, Zheng Y, Wei L, Cheng T, Wang Z, Guo Z, Zhou L.   +8 more
europepmc   +1 more source

Simultaneous Modeling of Protein Conformation and Dynamics via Autoregression [PDF]

arXiv
Understanding protein dynamics is critical for elucidating their biological functions. The increasing availability of molecular dynamics (MD) data enables the training of deep generative models to efficiently explore the conformational space of proteins.
arxiv  

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Pin1-Catalyzed Conformation Changes Regulate Protein Ubiquitination and Degradation

Cells
The unique prolyl isomerase Pin1 binds to and catalyzes cis–trans conformational changes of specific Ser/Thr-Pro motifs after phosphorylation, thereby playing a pivotal role in regulating the structure and function of its protein substrates.
Jessica Jeong, Muhammad Usman, Yitong Li, Xiao Zhen Zhou, Kun Ping Lu   +4 more
doaj   +1 more source

Chronic Wasting Disease (CWD) in Cervids and the Consequences of a Mutable Protein Conformation. [PDF]

ACS Omega, 2022
Silva CJ.
europepmc   +1 more source

Fast Sampling of Protein Conformational Dynamics [PDF]

arXiv
Protein function does not solely depend on structure but often relies on dynamical transitions between distinct conformations. Despite this fact, our ability to characterize or predict protein dynamics is substantially less developed compared to state-of-the-art protein structure prediction.
arxiv  

Stereochemical Criteria for Polypeptide and Protein Chain Conformations

, 1965
C. Ramakrishnan, G. N. Ramachandran
openalex   +1 more source

The conformation of DNA and protein within chromatin subunits [PDF]

, 1977
Rosalind I. Cotter
openalex   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Library screening identifies commercial drugs as potential structure correctors of abnormal apolipoprotein A-I

Journal of Lipid Research
AapoA-I, the main protein of high-density lipoprotein, plays a key role in the biogenesis and atheroprotective properties of high-density lipoprotein.
Christina Gkolfinopoulou, Angeliki Bourtsala, Daphne Georgiadou, Anastasia-Georgia Dedemadi, Efstratios Stratikos, Angeliki Chroni   +5 more
doaj