Results 131 to 140 of about 3,930,063 (310)

Pyramidalization of the Glycosidic Nitrogen Provides the Way for Efficient Cleavage of the N‑Glycosidic Bond of 8‑OxoG with the hOGG1 DNA Repair Protein [PDF]

, 2012
A mechanistic pathway for cleavage of the N-glycosidic bond of 8-oxo-2′-deoxyguanosine (oxoG) catalyzed with the human 8-oxoguanine glycosylase 1 DNA repair protein (hOGG1) is proposed in this theoretical study. The reaction scheme suggests direct proton
Sychrovský, V., Sub Cellular Protein Chemistry, Sebera, J., Tanaka, Y., Trantirek, L., Cellular Protein Chemistry   +5 more
core   +1 more source

In-cell single-molecule FRET measurement of cytosolic RAF proteins to investigate the structural states and kinetics among them

Frontiers in Molecular Biosciences
The structure of a protein is closely linked to its function. Many proteins undergo conformational changes while working in living cells. Consequently, proteins in various structural states coexist in the native cellular environment.
Kenji Okamoto, Yasushi Sako
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Amyloid diagnostics: Probing protein aggregation and conformation with ultrasensitive fluorescence detection

, 2012
While dozens of human ailments are now identified as "protein aggregation diseases", aggregation by itself does not seem to be a clear determinant of the toxicity.
Das, Anand K., Bhowmik, Debanjan, Singh, Niraj K., Sahoo, Banakanidhi, Meijer, Linda M., Maiti, Sudipta, Sarkar, Bidyut, Dandekar, Sucheta, Chandrakesan, Muralidharan, Nag, Suman, Abhyankar, Rajiv   +10 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Characterizing Protein Conformation Space [PDF]

, 2007
In this work, we propose a radical approach for exploring the space of all possible protein structures. We present techniques to explore the clash-free conformation space, which comprises all protein structures whose atoms are not in self-collision ...
Nigham, Anshul, Latombe, Jean-Claude, Hsu, David   +2 more
core  

Visualization of protein-protein interactions in the secretory pathway of mammalian cells [PDF]

, 2006
An increasing number of human disorders are being linked to mutations in components of the secretory pathway. One example is combined blood coagulation factor V and VIII deficiency, an autosomal recessive disorder leading to hemophilia due to markedly ...
Nyfeler, Beat
core   +1 more source

Antigen anisotropy: The overlooked geometric determinant of vaccine immunogenicity and fidelity

Human Vaccines & Immunotherapeutics
Antigen anisotropy, the directional dependence of protein conformation, epitope exposure, and conformational dynamics, is an under-appreciated determinant of vaccine immunogenicity.
Daniel Santiago
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Effect of Ultrasound Power on the Formation of Characteristic Flavors in Vinasse-cured Beef

Shipin gongye ke-ji
The effects of 200 W (UC200), 300 W (UC300) and 400 W (UC400) ultrasound assisted vinasse-curing on the formation of characteristic flavor in vinasse-cured beef were studied using beef as the fresh raw materials.
Junke ZHANG, Daodong PAN, Qiang XIA, Yangying SUN, Jinxuan CAO, Changyu ZHOU   +5 more
doaj   +1 more source