Results 141 to 150 of about 3,930,063 (310)

Protein conformation in a vaccine matters

Oncotarget, 2015
Vaccination is one of the most successful public health measures for control of viral diseases. Indeed, vaccines have either eliminated or considerably reduced many viral diseases worldwide. However, there are still many serious viral pathogens for which no vaccine is available. One of these pathogens is respiratory syncytial virus (RSV).
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Synergistic action of 60Co-γ irradiation on quality preservation of fresh-cut lotus root: microbial control and targeted polyphenol oxidase suppression

Food Innovation and Advances
Fresh-cut lotus root is highly susceptible to quality deterioration, primarily due to enzymatic browning and microbial growth. This study investigated the efficacy and mechanism of 60Co-γ irradiation in preserving the quality of fresh-cut lotus root. The
Dongjie Liu, Shihui Zhang, Feng Wang, Bifeng Lan, Xiaomei Wen, Gengsheng Xiao, Lukai Ma   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Protein Docking mit weichen Volumenmodellen [PDF]

, 2003
Neumann S. Soft volume models for protein-protein docking. Bielefeld (Germany): Bielefeld University; 2003.Der Begriff "Protein Docking" beschreibt die Frage, ob und wie zwei gegebene Proteine interagieren, ausgehend von der 3D Struktur.
Neumann, Steffen
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Conformation-dependent changes in DAT diffusion dynamics.

, 2019
Conformation-dependent changes in DAT diffusion dynamics.
Oleg Kovtun (1618660), Riley S. Ferguson (7907645), Sandra J. Rosenthal (1310463), Ian D. Tomlinson (1618675)   +3 more
core   +1 more source

Insights into the mechanism of reversible blood‐brain barrier opening via second near‐infrared region excited gold nanorods photothermal effect: Regulation of the tight junction protein occludin

Smart Molecules
This study constructed an in vitro blood‐brain barrier (BBB) transwell model to investigate the regulatory effects and mechanisms of the photothermal effects of gold nanorods (AuNRs) excited by the second near‐infrared region (NIR‐II) on BBB permeability.
Kaili Liang, Li Yang, Bo Liu, Xinying Wang, Liyan Wang, Jiawei Kang, Zhang Ding, Wei Wang, Qing Wang   +8 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Conformation-Sensitive Surface Dynamics in Thin Poly(ethylene terephthalate) Film

, 2019
The surface average conformation of poly­(ethylene terephthalate) (PET) films was modulated by adjusting the water content in corresponding trifluoroacetic acid (TFA) spin-coating solutions, which was confirmed by surface-sensitive sum frequency ...
Haosong Zhang (6458366), Jiachen Li (669381), Jianquan Xu (1529506), Xinping Wang (306022), Biao Zuo (1529497), Ophelia K. C. Tsui (1560706), Li Zhang (8200)   +6 more
core   +1 more source