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Conformation Polymorphism of Polyglutamine Proteins
Trends in Biochemical Sciences, 2018Expanded polyglutamine (polyQ) stretches within endogenous proteins cause at least nine human diseases. The structural basis of polyQ pathogenesis is the key to understanding fundamental mechanisms of these diseases, but it remains unclear and controversial due to a lack of polyQ protein structures at the single-atom level. Various hypotheses have been
Xinran Feng, Shouqing Luo, Boxun Lu
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Characterizing Intermediate Conformations in Protein Conformational Space
2013In this paper we present a novel parallel coordinate based clustering method using Gaussian mixture distribution models to characterize the conformational space of proteins. We detect highly populated regions which may correspond to intermediate states that are difficult to detect experimentally.
Rosanne Vetro +2 more
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Conformational interconversion in protein crystals
Journal of Molecular Biology, 1992We present evidence that the structure of carbonmonoxy myoglobin crystals can be altered by lowering the pH. This structural change is monitored by the characteristic Fe-CO Raman modes at 508 and 491 cm-1 and is thought to involve a localized distal pocket transition from a "closed" conformation at pH 7 to a more "open" conformation at pH 4.
L, Zhu +4 more
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Design of protein conformational switches
Current Opinion in Structural Biology, 2006Protein conformational switches are ubiquitous in nature and often regulate key biological processes. To design new proteins that can switch conformation, protein designers have focused on the two key components of protein switches: the amino acid sequence must be compatible with the multiple target states and there must be a mechanism for perturbing ...
Xavier I, Ambroggio, Brian, Kuhlman
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Conformational Changes in Protein Function
2008Conformational changes are the hallmarks of protein dynamics and are often intimately related to protein functions. Molecular dynamics (MD) simulation is a powerful tool to study the time-resolved properties of protein structure in atomic details.
Haiguang, Liu +5 more
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Conformational mobility of immobilized proteins
Journal of Pharmaceutical and Biomedical Analysis, 2007Cellular membrane fragments have been immobilized on the surface of a silica-based liquid chromatographic support and on the surface of glass capillaries to create immobilized receptor and drug transporter columns. These columns have included phases containing one subtype of the nicotinic receptor (alpha3beta2, alpha3beta4, alpha4beta2, alpha4beta4 ...
Ruin, Moaddel, Irving W, Wainer
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Protein conformation in bacterial spinae
Biopolymers, 1976AbstractThe far uv circular dichroism (CD) and infrared spectra of bacterial spinae are reported. Estimates of the protein secondary structure were obtained by three‐component curve‐fitting methods supplemented by rank and factor analysis of CD data matrices. Native spinae were shown to contain approximately 88% antiparallel β‐sheet, 7% α‐helix, and 5%
R W, Coombs +2 more
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Protein Conformational Dynamics
20141. Protein Folding Simulations by Generalized-ensemble Algorithms Takao Yoda, Yuji Sugita & Yuko Okamoto 2. Application of Markov State Models to Simulate Long Timescale Dynamics of Biological Macromolecules Lin-Tai Da, Fu Kit Sheong, Daniel-Adriano Silva & Xuhui Huang 3. Understanding Protein Dynamics Using Conformational Ensembles X.
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Prediction of protein conformation
Biochemistry, 1974P Y, Chou, G D, Fasman
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