Generative modeling of protein ensembles guided by crystallographic electron densities [PDF]
arXivProteins are dynamic, adopting ensembles of conformations. The nature of this conformational heterogenity is imprinted in the raw electron density measurements obtained from X-ray crystallography experiments. Fitting an ensemble of protein structures to these measurements is a challenging, ill-posed inverse problem. We propose a non-i.i.d.
arxiv
On the Conformational Stability of Globular Proteins
, 1965 Peter H. von Hippel, Kwok-Ying Wong
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PK Changes of Ionizable Reporter Groups as an Index of Conformational Changes in Proteins. A Study of Fluorescein-Labelled Ribonuclease A [PDF]
, 1976 Jean‐Renaud Garel
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Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
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New Inroads Into Our Understanding of the Tauopathies, Alzheimer's Disease, and the Contribution of Altered Protein Conformation to Human Neurological Disease. [PDF]
Front Neurosci, 2021 Lukiw WJ.
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Stereochemical Criteria for Polypeptide and Protein Chain Conformations
, 1966 G. N. Ramachandran +2 more
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Analysis of the code relating sequence to conformation in globular proteins. An informational analysis of the role of the residue in determining the conformation of its neighbours in the primary sequence [PDF]
, 1974 Barry Robson, Roger H. Pain
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Molecular Oncology, EarlyView.This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci +6 more
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The prediction of the conformation of membrane proteins from the sequence of amino acids [PDF]
, 1976 N M Green, Michael T. Flanagan
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