Results 191 to 200 of about 3,930,063 (310)

Atomic Structure of the Human Sapovirus Capsid Reveals a Unique Capsid Protein Conformation in Caliciviruses. [PDF]

J Virol, 2022
Miyazaki N, Song C, Oka T, Miki M, Murakami K, Iwasaki K, Katayama K, Murata K.   +7 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Generative Autoencoders Coupled to Monte Carlo Simulation Allow Efficient Protein Conformation Sampling. [PDF]

J Chem Theory Comput
Beránek J, Tedeschi G, Spiwok V.
europepmc   +1 more source

Effect of Oudemansiella raphanipies Powder on Physicochemical and Textural Properties, Water Distribution and Protein Conformation of Lower-Fat Pork Meat Batter. [PDF]

Foods, 2022
Zhao Y, Wang Y, Li K, Mazurenko I.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Protein-adhesive and protein-resistant functionalized silicon surfaces [PDF]

A series of new ω-alkenyl tertiary amine N-oxides is prepared in solution and immobilized on hydrofluoric acid-etched silicon {111} wafers. These monolayers are characterized by X-ray photoelectron spectroscopy, contact angle measurements, atomic force ...
Cooper, Amy L., Evans, Stephen D., Johnson, Benjamin R. G., Taylor, Paul C., Haynes, Tommy, Dobrzanska, Dorota A., Stec, Helena M., Marsh, Andrew, Dowson, Christopher G.   +8 more
core  

Integrated LiP-MS and quantitative proteomics reveal coordinated alterations in protein conformation and expression across tumor and peritumoral regions in hepatocellular carcinoma. [PDF]

Sci Rep
Chen ZD, Yang MY, Wei XN, Qin W, Xiao L, Qin YY, Su RL, Dang YW, Xiong DD.   +8 more
europepmc   +1 more source

New Inroads Into Our Understanding of the Tauopathies, Alzheimer's Disease, and the Contribution of Altered Protein Conformation to Human Neurological Disease. [PDF]

Front Neurosci, 2021
Lukiw WJ.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Publisher Correction: Activity-dependent ribosome profiling reveals the landscape of canonical and non-canonical translation in brain tissue

Nature Communications
Nayan Suryawanshi, Hitoshi Uchida, Ryo Endo, Kai Sato, Daisuke Satoh, Kazuya Tsumagari, Koshi Imami, Takayasu Mikuni, Motomasa Tanaka   +8 more
doaj   +1 more source