Results 201 to 210 of about 6,634,608 (387)

Detection of Cis-Trans Conformation in Protein Structure using Deep Learning Neural Network Techniques

, 2019
Jaswinder Singh
openalex   +2 more sources

Finding low-energy conformations of lattice protein models by quantum annealing [PDF]

, 2012
Alejandro Perdomo‐Ortiz, Neil G. Dickson, Marshall Drew-Brook, Geordie Rose, Alán Aspuru‐Guzik   +4 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Protein Conformation Governs Spin-Selective Electron Transmission. [PDF]

J Phys Chem Lett
Preeyanka N, Das TK, Naaman R.
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Understanding conformational transitions in RAS proteins using all-atom and coarse-grained molecular dynamics

, 2014
Abhijeet Kapoor
openalex   +2 more sources

Vitamin A Emulsion Encapsulated with Whey Protein Isolate-Soybean Lecithin Enhances Surimi Gel Structure and Protein Conformation. [PDF]

Foods
Chen M, Huang X, Lin Y, Yi S.
europepmc   +1 more source

Coevolutionary signals across protein lineages help capture multiple protein conformations [PDF]

, 2013
Faruck Morcos, Biman Jana, Terence Hwa, José N. Onuchic   +3 more
openalex   +1 more source

Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies [PDF]

, 2020
Ivan Mercurio, Vincenzo Tragni, Francesco Busco, Anna Grassi, Ciro Leonardo Pierri   +4 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source