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The ABC of protein kinase conformations
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2015Due to their involvement in human diseases, protein kinases are an important therapeutic target class. Conformation is a key concept for understanding how functional activity, inhibition and sequence are linked. We assemble and annotate the mammalian structural kinome from the Protein Data Bank on the basis of a universal residue nomenclature.
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Conformational Changes in Protein Function
2008Conformational changes are the hallmarks of protein dynamics and are often intimately related to protein functions. Molecular dynamics (MD) simulation is a powerful tool to study the time-resolved properties of protein structure in atomic details.
Haiguang, Liu +5 more
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Native conformation of M-protein
Biochemical and Biophysical Research Communications, 1975The purification of the M-Protein isolated from a myofibrilar M-line extract is described. Its molecular weight at low ionic strength calculated by YPHANTIS method is equal to 160 000. Optical rotatory dispersion and circular dichroism spectra indicate the presence of about 30 % β-structure and a low α-helical content.
M F, Landon, C, Oriol
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Conformational issues in the characterization of proteins
Biotechnology and Applied Biochemistry, 2000The conformation of a protein refers to the three‐dimensional arrangement of its constituent atoms. Since expression of the biological activity of a protein depends on its conformation, it is clear that full characterization of a protein involves an understanding of its three‐dimensional structure.
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Prediction of protein conformation
Biochemistry, 1974P Y, Chou, G D, Fasman
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Conformational Substates in Proteins
Annual Review of Biophysics and Biophysical Chemistry, 1988H, Frauenfelder, F, Parak, R D, Young
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Conformation of engineered proteins
Biotechnology and Applied Biochemistry, 1999R L, Lundblad, R A, Bradshaw
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