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The ABC of protein kinase conformations

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2015
Due to their involvement in human diseases, protein kinases are an important therapeutic target class. Conformation is a key concept for understanding how functional activity, inhibition and sequence are linked. We assemble and annotate the mammalian structural kinome from the Protein Data Bank on the basis of a universal residue nomenclature.
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Conformational Changes in Protein Function

2008
Conformational changes are the hallmarks of protein dynamics and are often intimately related to protein functions. Molecular dynamics (MD) simulation is a powerful tool to study the time-resolved properties of protein structure in atomic details.
Haiguang, Liu   +5 more
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Native conformation of M-protein

Biochemical and Biophysical Research Communications, 1975
The purification of the M-Protein isolated from a myofibrilar M-line extract is described. Its molecular weight at low ionic strength calculated by YPHANTIS method is equal to 160 000. Optical rotatory dispersion and circular dichroism spectra indicate the presence of about 30 % β-structure and a low α-helical content.
M F, Landon, C, Oriol
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Conformation of Proteins

Annual Review of Biochemistry, 1967
S N, Timasheff, M J, Gorbunoff
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Conformational issues in the characterization of proteins

Biotechnology and Applied Biochemistry, 2000
The conformation of a protein refers to the three‐dimensional arrangement of its constituent atoms. Since expression of the biological activity of a protein depends on its conformation, it is clear that full characterization of a protein involves an understanding of its three‐dimensional structure.
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Conformational Substates in Proteins

Annual Review of Biophysics and Biophysical Chemistry, 1988
H, Frauenfelder, F, Parak, R D, Young
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Conformation of engineered proteins

Biotechnology and Applied Biochemistry, 1999
R L, Lundblad, R A, Bradshaw
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