Results 71 to 80 of about 6,585,847 (336)

Understanding protein diffusion on force-induced stretched DNA conformation

Frontiers in Molecular Biosciences, 2022
DNA morphology is subjected to environmental conditions and is closely coupled with its function. For example, DNA experiences stretching forces during several biological processes, including transcription and genome transactions, that significantly ...
Anupam Mondal, Arnab Bhattacherjee
doaj   +1 more source

ATPase mechanism of the 5'-3' DNA helicase, RecD2: evidence for a pre-hydrolysis conformation change [PDF]

, 2013
The superfamily 1 helicase, RecD2, is a monomeric, bacterial enzyme with a role in DNA repair, but with 5'-3' activity unlike most enzymes from this superfamily. Rate constants were determined for steps within the ATPase cycle of RecD2 in the presence of
Bae, Bird, Boulé, Brune, Brune, Cao, Chisty, Christopher P. Toseland, Cremo, Dillingham, Gu, Henn, Henn, Hiratsuka, Ivessa, Jameson, Leatherbarrow, Lohman, Manosas, Martin R. Webb, Moore, Nixon, Okoh, Rocha, Saikrishnan, Singleton, Slatter, Soultanas, Toseland, Toseland, Toseland, Toseland, Wang, Webb, Webb   +34 more
core   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Progress on the Mechanism of Interaction between Volatile Flavor Substances and Muscle Proteins

Shipin gongye ke-ji
Flavor significantly influences the quality of meat and meat products. The dynamic equilibrium between the release and retention of volatile flavor compounds, influenced by the interaction of muscle proteins and flavor compounds, is crucial in ...
Meng WEI, Wenna ZHANG, Aiyun HAN, Libin XIE, Xiaochang LIU, Songshan ZHANG, Peng XIE, Baozhong SUN   +7 more
doaj   +1 more source

Effect of bamboo shoot dietary fiber on gel quality, thermal stability and secondary structure changes of pork salt-soluble proteins

CyTA - Journal of Food, 2019
The effect of bamboo shoot dietary fibre (BSDF) (0%-4%) on the gel quality, protein thermal stability and secondary structure of pork salt-soluble proteins (SSP) was investigated.
Ke Li, Jun-Ya Liu, Yan-Hong Bai, Ying-Ying Zhao, Yan-Yan Zhang, Jun-Guang Li, Hua Zhang, Diao-Bo Zhao   +7 more
doaj   +1 more source

Protein Conformational Dynamics upon Association with the Surfaces of Lipid Membranes and Engineered Nanoparticles: Insights from Electron Paramagnetic Resonance Spectroscopy

Molecules, 2020
Detailed study of conformational rearrangements and dynamics of proteins is central to our understanding of their physiological functions and the loss of function.
Elka R. Georgieva
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Types and Strains: Their Essential Role in Understanding Protein Aggregation in Neurodegenerative Diseases

Frontiers in Aging Neuroscience, 2017
Protein misfolding and aggregation is a key event in diseases like Alzheimer’s disease (AD) or Parkinson’s disease (PD) and is associated with neurodegeneration.
Wiebke M. Wemheuer, Wiebke M. Wemheuer, Arne Wrede, Arne Wrede, Walter J. Schulz-Schaeffer, Walter J. Schulz-Schaeffer   +5 more
doaj   +1 more source

Role of Pre-molten Globule Structure in Protein Amyloid Fibril Formation [PDF]

Avicenna Journal of Medical Biochemistry, 2019
The conversion of a protein from its native conformation to the pathogenic form is a critical event in the pathogenesis of several neurodegenerative disorders such as Alzheimer’s (AD), Parkinson’s, and Huntington’s diseases, along with type II diabetic ...
Ali Es-haghi, Mahsa Jahedi Moghaddam, Koorosh Shahpasand   +2 more
doaj   +1 more source