Results 81 to 90 of about 3,930,063 (310)

Structure motivator: a tool for exploring small three-dimensional elements in proteins [PDF]

, 2012
<br>Background: Protein structures incorporate characteristic three-dimensional elements defined by some or all of hydrogen bonding, dihedral angles and amino acid sequence.
Milner-White, E.J., David P Leader, E Milner-White, Leader, D.P.   +3 more
core   +1 more source

Isoflurane's Effect on Protein Conformation as a Proposed Mechanism for Preconditioning

Biochemistry Research International, 2011
Persistent alteration of protein conformation due to interaction with isoflurane may be a novel molecular aspect of preconditioning. We preincubated human serum albumin with isoflurane, dialyzed to release agent, and assessed protein conformation ...
Michelle R. Baker, Sean K. Benton, Christopher S. Theisen, Chad A. McClintick, Eugene E. Fibuch, Norbert W. Seidler   +5 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The presence of valine at residue 129 in human prion protein accelerates amyloid formation [PDF]

, 2005
The polymorphism at residue 129 of the human PRNP gene modulates disease susceptibility and the clinicopathological phenotypes in human transmissible spongiform encephalopathies.
Tahiri-Alaoui, Abdessamad, Gill, A, Shaw, Michael, Shaw, M, Baskakov, I, Breydo, L, James, W, Tahiri-Alaoui, A, Disterer, Petra, Gill, Andrew, Baskakov, Ilia, Breydo, Leonid, Disterer, P, James, William   +13 more
core   +1 more source

Library screening identifies commercial drugs as potential structure correctors of abnormal apolipoprotein A-I

Journal of Lipid Research
AapoA-I, the main protein of high-density lipoprotein, plays a key role in the biogenesis and atheroprotective properties of high-density lipoprotein.
Christina Gkolfinopoulou, Angeliki Bourtsala, Daphne Georgiadou, Anastasia-Georgia Dedemadi, Efstratios Stratikos, Angeliki Chroni   +5 more
doaj   +1 more source

Reactive Human Plasma Glutathione Peroxidase Mutant with Diselenide Bond Succeeds in Tetramer Formation

Antioxidants, 2022
Plasma glutathione peroxidase (GPx3) belongs to the GPx superfamily, and it is the only known secreted selenocysteine (Sec)−containing GPx in humans.
Zhenlin Fan, Qi Yan, Jian Song, Jingyan Wei   +3 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Biochemical Properties of Human D-amino Acid Oxidase Variants and Their Potential Significance in Pathologies

Frontiers in Molecular Biosciences, 2018
The stereoselective flavoenzyme D-amino acid oxidase (DAAO) catalyzes the oxidative deamination of neutral and polar D-amino acids producing the corresponding α-keto acids, ammonia, and hydrogen peroxide.
Silvia Sacchi, Silvia Sacchi, Pamela Cappelletti, Pamela Cappelletti, Giulia Murtas   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Protein-induced changes in DNA structure and dynamics observed with noncovalent site-directed spin-labeling and PELDOR [PDF]

, 2012
Site-directed spin labeling and pulsed electron–electron double resonance (PELDOR or DEER) have previously been applied successfully to study the structure and dynamics of nucleic acids. Spin labeling nucleic acids at specific sites requires the covalent
Reginsson, Gunnar Widtfeldt, Rouillon, Christophe, Schiemann, Olav, Sigurdsson, Snorri T, White, Malcolm F, Shelke, Sandip   +5 more
core   +1 more source