Results 101 to 110 of about 3,930,063 (310)

Effects of the Addition Amount of Citrus Fiber on the Gel Properties of Nemipterus virgatus Surimi

Shipin gongye ke-ji
To improve the gel quality of surimi products, this study investigated the effects of adding Citrus fiber at different mass fractions (0%, 0.5%, 1.0%, 1.5%, 2%) on the gel properties and microstructure of Nemipterus virgatus surimi.
Yuting WANG, Honglei ZHAO, Yongxia XU, Shumin YI, Xuepeng LI, Jianrong LI, Guangren JI   +6 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Accurate modeling of protein structures by homology [PDF]

, 2013
Proteins are macromolecules which play a crucial role in virtually any process in the living cell. The determination of the 3-dimensional structure of a protein is a key component in understanding its function and mode of action.
Biasini, Marco
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The effect of neutral sugar distribution on the dilute solution conformation of sugar beet pectin [PDF]

, 2012
A partially degraded sugar beet pectin (C) was found to be heterogeneous in composition with neutral sugar-rich fractions of both high and low hydrodynamic radii. A neutral sugar-poor fraction was found at intermediate hydrodynamic radii.
Morris, Gordon, Ralet, M.C., Ralet, Marie-Christine, Ralet, Marie Christine, Morris, Gordon A.   +4 more
core   +1 more source

Protein Conformational Dynamics upon Association with the Surfaces of Lipid Membranes and Engineered Nanoparticles: Insights from Electron Paramagnetic Resonance Spectroscopy

Molecules, 2020
Detailed study of conformational rearrangements and dynamics of proteins is central to our understanding of their physiological functions and the loss of function.
Elka R. Georgieva
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Types and Strains: Their Essential Role in Understanding Protein Aggregation in Neurodegenerative Diseases

Frontiers in Aging Neuroscience, 2017
Protein misfolding and aggregation is a key event in diseases like Alzheimer’s disease (AD) or Parkinson’s disease (PD) and is associated with neurodegeneration.
Wiebke M. Wemheuer, Wiebke M. Wemheuer, Arne Wrede, Arne Wrede, Walter J. Schulz-Schaeffer, Walter J. Schulz-Schaeffer   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source