Results 151 to 160 of about 3,834,350 (184)
Some of the next articles are maybe not open access.
Surfactant Titration of Nanoparticle–Protein Corona
Analytical Chemistry, 2014Nanoparticles (NP), when exposed to biological fluids, are coated by specific proteins that form the so-called protein corona. While some adsorbing proteins exchange with the surroundings on a short time scale, described as a "dynamic" corona, others with higher affinity and long-lived interaction with the NP surface form a "hard" corona (HC), which is
MAIOLO, Daniele +4 more
openaire +3 more sources
Manipulation of protein corona for nanomedicines
WIREs Nanomedicine and NanobiotechnologyAbstractNanomedicines have significantly advanced the development of diagnostic and therapeutic strategies for various diseases, while they still encounter numerous challenges. Upon entry into the human body, nanomedicines interact with biomolecules to form a layer of proteins, which is defined as the protein corona that influences the biological ...
Tao Li, Yupeng Wang, Dongfang Zhou
openaire +2 more sources
Nanoparticle and Protein Corona
2013Nanoparticles and other nanomaterials are increasingly considered for use in biomedical applications such as imaging, drug delivery, and hyperthermic therapies. Thus, understanding the interaction of nanomaterials with biological systems becomes key for their safe and efficient application.
Masoud Rahman +4 more
openaire +1 more source
Protein corona formation for nanomaterials and proteins of a similar size: hard or soft corona?
Nanoscale, 2013Nanoparticles (NPs) entering a biological fluid undergo surface modification due to dynamic, physicochemical interactions with biological components, especially proteins. In this work we used complementary bio-physico-chemical approaches to characterize the effects of interactions between CeO(2) NPs, immunoglobulins (IgGs) and bovine serum albumin (BSA)
Liu, Wei +5 more
openaire +5 more sources
Analytical and Bioanalytical Chemistry, 2022
Nanoparticles in contact with proteins form a "corona" of proteins adsorbed on the nanoparticle surface. Subsequent biological responses are then mediated by the adsorbed proteins rather than the bare nanoparticles. The use of nanoparticles as nanomedicines and biosensors would be greatly improved if researchers were able to predict which specific ...
Karsten M, Poulsen, Christine K, Payne
openaire +2 more sources
Nanoparticles in contact with proteins form a "corona" of proteins adsorbed on the nanoparticle surface. Subsequent biological responses are then mediated by the adsorbed proteins rather than the bare nanoparticles. The use of nanoparticles as nanomedicines and biosensors would be greatly improved if researchers were able to predict which specific ...
Karsten M, Poulsen, Christine K, Payne
openaire +2 more sources
Towards understanding of nanoparticle–protein corona
Archives of Toxicology, 2015With the rapid developments of nanotechnology, chances of exposing nanoscale particles to humans (e.g., workers and consumers) also increase correspondingly, which raises serious concerns on their biosafety. Entrance of nanoparticles into diverse biological environment endows them with new and dynamic biological identities as the so-called nanoparticle-
Cuicui, Ge +5 more
openaire +2 more sources
Understanding the Kinetics of Protein–Nanoparticle Corona Formation
ACS Nano, 2016 Abstract When a pristine nanoparticle (NP) encounters a biological fluid, biomolecules spontaneously form adsorption layers around the NP, called “protein corona”. The corona composition depends on the time-dependent environmental conditions and determines the NP’s fate within living organisms.
Philip M Kelly +2 more
exaly +3 more sources
Serum proteins on nanoparticles: early stages of the “protein corona”
Nanoscale, 2021Nanoparticles are studied with respect to serum albumin binding using a direct and quantitative approach. We find that protein binding saturation occurs at sub-monolayer surface coverage and attribute binding to surface chemistry heterogeneity.
Sarah McColman +5 more
openaire +2 more sources
Inside the Protein Corona: From Binding Parameters to Unstained Hard and Soft Coronas Visualization
Nano Letters, 2021Proteins spontaneously adsorb on nanoparticle surfaces when injected into the bloodstream. It drastically modifies the nanoparticle's fate and how they interact with organs and cells. Although this protein layer (protein corona) has been widely studied, the robustness of the most employed characterization methods and the visualization of its unstained ...
Flávia E. Galdino +4 more
openaire +3 more sources
Formation and Characterization of the Nanoparticle–Protein Corona
2013Over the last decade the existence of "the corona," a natural interface between nanomaterials and living matter in biological milieu, evolved from a vague concept into broadly recognized fact. This robust shell arises (to some extent) on the surface of all nanoparticles (NPs), even the ones designed to avoid its formation upon contact with biological ...
Marco P, Monopoli +3 more
openaire +2 more sources