Results 131 to 140 of about 103,093 (251)

High pressure macromolecular crystallography for structural biology: a review

Open Life Sciences, 2010
Kurpiewska Katarzyna, Lewiński Krzysztof   +1 more
doaj   +1 more source

Major Cat Allergen Fel d 4: Structure and Identification of a Cross‐Reactive IgE‐Epitope‐Containing Area

Allergy, EarlyView.
This study reports the three‐dimensional structure of an important cat allergen, Fel d 4, that shares high homology with Equ c 1 (i.e., major horse allergen) and Can f 6 (i.e., dog allergen). The C‐terminal region of the Fel d 4 contains a major IgE‐reactive epitope.
Nikolina Todorović, Daria Trifonova, Zicheng Liu, Mirela Curin, Laszlo Schooltink, Theo Sagmeister, Christoph Grininger, Renata Kiss, Nina Gottstein, Bernd Gesslbauer, Andreas Winkler, Tea Pavkov‐Keller, Alexander Karaulov, Rudolf Valenta, Walter Keller   +14 more
wiley   +1 more source

High-speed protein crystallography [PDF]

Nature Methods, 2018
openaire   +2 more sources

Genetic Algorithm-Enhanced Direct Method in Protein Crystallography. [PDF]

Molecules
Fu R, Su WP, He H.
europepmc   +1 more source

Protein Crystallography

Journal of Pesticide Science, 2003
openaire   +2 more sources

Network medicine and systems pharmacology approaches to predicting adverse drug effects

British Journal of Pharmacology, EarlyView.
Identifying and understanding the relationships between drug intake and adverse effects that can occur due to inadvertent molecular interactions between drugs and targets is a difficult task, especially considering the numerous variables that can influence the onset of such events.
Alessio Funari, Giulia Fiscon, Paola Paci   +2 more
wiley   +1 more source

Artificial intelligence streamlines scientific discovery of drug–target interactions

British Journal of Pharmacology, EarlyView.
Abstract Drug discovery is a complicated process through which new therapeutics are identified to prevent and treat specific diseases. Identification of drug–target interactions (DTIs) stands as a pivotal aspect within the realm of drug discovery and development. The traditional process of drug discovery, especially identification of DTIs, is marked by
Yuxin Yang, Feixiong Cheng
wiley   +1 more source

Dissecting the Mechanism of (<i>R</i>)-3-Hydroxybutyrate Dehydrogenase by Kinetic Isotope Effects, Protein Crystallography, and Computational Chemistry. [PDF]

ACS Catal, 2020
Machado TFG, Purg M, McMahon SA, Read BJ, Oehler V, Åqvist J, Gloster TM, da Silva RG.   +7 more
europepmc   +1 more source

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

British Journal of Pharmacology, EarlyView.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck, Mario van der Stelt   +1 more
wiley   +1 more source

On-the-fly resolution enhancement in X-ray protein crystallography using electric field. [PDF]

Eur Biophys J
Khakurel KP, Nemergut M, Pant P, Savko M, Andreasson J, Žoldák G.   +5 more
europepmc   +1 more source