Results 181 to 190 of about 103,093 (251)
Ten Good Reasons for the Use of the Tellurium-Centered Anderson-Evans Polyoxotungstate in Protein Crystallography. [PDF]
Bijelic A, Rompel A.
europepmc +1 more source
Metal‐Directed Self‐Assembly in a Beta‐Sheet Miniprotein Scaffold
A rationally engineered miniprotein, V14C, which is based on the beta β‐sheet Foldon domain, self‐assembles via a metal‐binding site to form well‐defined oligomers in the presence of Zn2+, Hg2+, and Cd2+. This modular design expands the toolbox for creating custom metalloproteins, enabling studies of metal–protein interactions for biochemical functions
Chandan Muni Reddy +3 more
wiley +1 more source
Optimizing Crystal Size of Photosystem II by Macroseeding: Toward Neutron Protein Crystallography. [PDF]
Hussein R +9 more
europepmc +1 more source
Homologous expression and purification of human HAX‐1 for structural studies
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
Protein Crystallography in Vaccine Research and Development. [PDF]
Malito E, Carfi A, Bottomley MJ.
europepmc +1 more source
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen +22 more
wiley +1 more source
Protein crystallography and drug discovery: recollections of knowledge exchange between academia and industry. [PDF]
Blundell TL.
europepmc +1 more source
Acrylamide is found in many common foods and presents toxicity concerns. Its current detection methods are time consuming, costly, and environmentally unsustainable. This study presents an acrylamide detection methodology based on surface enhanced Raman spectroscopy (SERS) using gold nanoparticles on titanium oxide nanowires, with focus on reducing ...
Maria Tarapoulouzi +5 more
wiley +1 more source
Probing Attractive OH−π Interactions and Repulsive n−π Interactions in a Phenol Molecular Balance
This work introduces a 2,6‐diarylphenol molecular balance that enables direct comparison of competing intramolecular attractive OH–π interactions and repulsive O–π interactions. Through combined experimental and computational studies, we show that the phenolic OH group selectively interacts with electron‐rich aromatic rings by avoiding repulsive O–π ...
Jie Jian +5 more
wiley +1 more source
Light‐Based Molecular Tools to Precisely Monitor and Operate β‐Adrenoceptors
ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Ignazzitto Maria Tindara +3 more
wiley +1 more source

