Results 111 to 120 of about 4,646,061 (279)

Navigating public microarray databases [PDF]

, 2004
With the ever-escalating amount of data being produced by genome-wide microarray studies, it is of increasing importance that these data are captured in public databases so that researchers can use this information to complement and enhance their own ...
Bähler, J, Penkett, CJ
core  

Picky Hsp90-Every Game with Another Mate [PDF]

, 2017
In this issue of Molecular Cell, Sahasrabudhe et al. (2017) present a dramatically renovated functional cycle for the molecular chaperone Hsp90, which stimulates re-thinking of the mechanism of this vital protein folding ...
Sub Cellular Protein Chemistry, Rüdiger, Stefan G D, Radli, Martina, Cellular Protein Chemistry   +3 more
core   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

dbMPIKT: a database of kinetic and thermodynamic mutant protein interactions

BMC Bioinformatics, 2018
Background Protein-protein interactions (PPIs) play important roles in biological functions. Studies of the effects of mutants on protein interactions can provide further understanding of PPIs.
Quanya Liu, Peng Chen, Bing Wang, Jun Zhang, Jinyan Li   +4 more
doaj   +1 more source

Optimization-Based Peptide Mass Fingerprinting for Protein Mixture Identification [PDF]

, 2008
*Motivation:* In current proteome research, peptide sequencing is probably the most widely used method for protein mixture identification. However, this peptide-centric method has its own disadvantages such as the immense volume of tandem Mass ...
Zengyou He, Jason Po-Ming Tam, Chao Yang, Weichuan Yu, Robert Z Qi, Can Yang   +5 more
core  

The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases [PDF]

, 2016
The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to
Swiss Institute of Bioinformatics Members, SIB, SIB Swiss Institute of Bioinformatics   +1 more
core   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

ProteoDisco: a flexible R approach to generate customized protein databases for extended search space of novel and variant proteins in proteogenomic studies. [PDF]

Bioinformatics, 2022
van de Geer WS, van Riet J, van de Werken HJG.   +2 more
europepmc   +1 more source

ISPIDER Central: an integrated database web-server for proteomics [PDF]

, 2008
Despite the growing volumes of proteomic data, integration of the underlying results remains problematic owing to differences in formats, data captured, protein accessions and services available from the individual repositories.
Zamboulis, L., Pentony, Melissa M., Poulovassillis, Alexandra, Hubbard, S.J., Orengo, Christine A., Belhajjame, K., Selley, J.N., Orengo, C.A., Côté, Richard, Zamboulis, Lucas, Siepen, Jennifer A., Oliver, Stephen G., Jones, D.T., Goble, C.A., Oliver, S.G., Selley, Julian N., Embury, Suzanne M.; id_orcid, Siepen, J.A., Jones, Philip, Stevens, R., Embury, S.M., Côté, R., Jones, David T., Hubbard, Simon J.; id_orcid, Hermjakob, Henning, Poulovassilis, Alexandra, Jones, P., Goble, Carole A., Paton, N.W., Martin, Nigel, Pentony, M.M., Hermjakob, H., Paton, Norman W.; id_orcid, Belhajjame, Khalid, Stevens, Robert   +34 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source