Results 151 to 160 of about 542,906 (295)

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Hierarchical classification of G-protein-coupled receptors with a PSO/ACO algorithm [PDF]

, 2006
In our previous work we have proposed a hybrid Particle Swarm Optimisation / Ant Colony Optimisation (PSO/ACO) algorithm for discovering classification rules.
Holden, Nicholas, Freitas, Alex A.
core  

Representing and analysing molecular and cellular function in the computer

, 2000
Determining the biological function of a myriad of genes, and understanding how they interact to yield a living cell, is the major challenge of the post genome-sequencing era.
Naim, A., Helden, J., Van, Wernisch, L, Eldridge, M, Wodak, S. J., Gilbert, D, Mancuso, R, Helden, JV, Wodak, SJ, Helden, J.,, Wernisch, Lorenz, Naim, A, Wernisch, L., Eldridge, Matthew, van Helden, Jacques, Mancuso, R., Wodak, Shoshana, Eldridge, M., Mancuso, Renato, Gilbert, D.   +19 more
core   +1 more source

Protein structure prediction via deep learning: an in-depth review

Frontiers in Pharmacology
The application of deep learning algorithms in protein structure prediction has greatly influenced drug discovery and development. Accurate protein structures are crucial for understanding biological processes and designing effective therapeutics ...
Yajie Meng, Zhuang Zhang, Chang Zhou, Xianfang Tang, Xinrong Hu, Geng Tian, Jialiang Yang, Yuhua Yao, Yuhua Yao, Yuhua Yao   +9 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Modern Approaches to Protein Constructions: A Comprehensive Review of Computational Tools and Databases for De Novo Protein Design and Engineering

Engineering Reports
The field of protein engineering has witnessed transformative advancements, with computational tools and databases driving novel innovations in de novo protein design.
Md. Mojnu Mia, Habiba Sultana, Md. Al Amin, Md. Sakhawat Hossain, Hasan Imam, A. K. M. Mohiuddin, Shahin Mahmud   +6 more
doaj   +1 more source

Advancements in one-dimensional protein structure prediction using machine learning and deep learning

Computational and Structural Biotechnology Journal
The accurate prediction of protein structures remains a cornerstone challenge in structural bioinformatics, essential for understanding the intricate relationship between protein sequence, structure, and function. Recent advancements in Machine Learning (
Wafa Alanazi, Di Meng, Gianluca Pollastri   +2 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

A computer system to perform structure comparison using TOPS representations of protein structure

, 2001
We describe the design and implementation of a fast topology–based method for protein structure comparison. The approach uses the TOPS topological representation of protein structure, aligning two structures using a common discovered pattern and ...
Viksna, J, Gilbert, D, Thornton, J, Westhead, V   +3 more
core  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source