Results 171 to 180 of about 8,374,602 (379)

SCOPe: improvements to the structural classification of proteins – extended database to facilitate variant interpretation and machine learning

, 2021
John‐Marc Chandonia, Lindsey Guan, Shiangyi Lin, Changhua Yu, Naomi K. Fox, Steven E. Brenner   +5 more
openalex   +1 more source

Clustering of highly homologous sequences to reduce the size of large protein databases

Bioinform., 2001
Weizhong Li, L. Jaroszewski, A. Godzik
semanticscholar   +1 more source

Where differences resemble: sequence-feature analysis in curated databases of intrinsically disordered proteins [PDF]

, 2018
Apweiler, Bardou, Brown, Damiano Piovesan, Das, Daughdrill, Dinkel, Dunker, Dunker, Dunker, Dyson, Fichó, Fu, Fukuchi, Gunasekaran, Holehouse, Lee, Marco Necci, Miskei, Mészáros, Necci, Necci, Peng, Piovesan, Piovesan, Piovesan, Radivojac, Receveur-Bréchot, Schad, Silvio C E Tosatto, The Gene Ontology Consortium, Tompa, Uversky, Van Roey, Vucetic, Ward, Wootton, Wright, Xue   +38 more
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Protein structure prediction via deep learning: an in-depth review

Frontiers in Pharmacology
The application of deep learning algorithms in protein structure prediction has greatly influenced drug discovery and development. Accurate protein structures are crucial for understanding biological processes and designing effective therapeutics ...
Yajie Meng, Zhuang Zhang, Chang Zhou, Xianfang Tang, Xinrong Hu, Geng Tian, Jialiang Yang, Yuhua Yao, Yuhua Yao, Yuhua Yao   +9 more
doaj   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Advancements in one-dimensional protein structure prediction using machine learning and deep learning

Computational and Structural Biotechnology Journal
The accurate prediction of protein structures remains a cornerstone challenge in structural bioinformatics, essential for understanding the intricate relationship between protein sequence, structure, and function. Recent advancements in Machine Learning (
Wafa Alanazi, Di Meng, Gianluca Pollastri   +2 more
doaj   +1 more source

The SCOP database in 2020: expanded classification of representative family and superfamily domains of known protein structures [PDF]

, 2019
Antonina Andreeva, Eugene Kulesha, Julian Gough, Alexey G. Murzin   +3 more
openalex   +1 more source