Results 71 to 80 of about 8,374,602 (379)
Comparison of false-discovery rates of various decoy databases
Proteome Science, 2021 Background The target-decoy strategy effectively estimates the false-discovery rate (FDR) by creating a decoy database with a size identical to that of the target database.
Sangjeong Lee, Heejin Park, Hyunwoo Kim
doaj +1 more source
An Investigation of Alternatives to Transform Protein Sequence Databases to a Columnar Index Schema
Algorithms, 2021 Mass spectrometers enable identifying proteins in biological samples leading to biomarkers for biological process parameters and diseases. However, bioinformatic evaluation of the mass spectrometer data needs a standardized workflow and system that ...
Roman Zoun +7 more
doaj +1 more source
Prefix-Projection Global Constraint for Sequential Pattern Mining [PDF]
, 2015 Sequential pattern mining under constraints is a challenging data mining task. Many efficient ad hoc methods have been developed for mining sequential patterns, but they are all suffering from a lack of genericity.
B Negrevergne +7 more
core +2 more sources
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
The potential of text mining in data integration and network biology for plant research : a case study on Arabidopsis [PDF]
, 2013 Despite the availability of various data repositories for plant research, a wealth of information currently remains hidden within the biomolecular literature. Text mining provides the necessary means to retrieve these data through automated processing of
De Bodt, Stefanie +4 more
core +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
EffHunter: A Tool for Prediction of Effector Protein Candidates in Fungal Proteomic Databases
Biomolecules, 2020 Pathogens are able to deliver small-secreted, cysteine-rich proteins into plant cells to enable infection. The computational prediction of effector proteins remains one of the most challenging areas in the study of plant fungi interactions.
Karla Gisel Carreón-Anguiano +4 more
doaj +1 more source
Molecular & Cellular Proteomics, 2006 A fairly large set of protein interactions is mediated by families of peptide binding domains, such as Src homology 2 (SH2), SH3, PDZ, major histocompatibility complex, etc.
Ling Zhang +3 more
semanticscholar +1 more source
SERpredict: Detection of tissue- or tumor-specific isoforms generated through exonization of transposable elements [PDF]
, 2007 Background: Transposed elements (TEs) are known to affect transcriptomes, because either new exons are generated from intronic transposed elements (this is called exonization), or the element inserts into the exon, leading to a new transcript.
Ast, Gil +4 more
core +3 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source