Results 51 to 60 of about 542,906 (295)
Comparative Assessment of Protein Kinase Inhibitors in Public Databases and in PKIDB
Molecules, 2020 Since the first approval of a protein kinase inhibitor (PKI) by the Food and Drug Administration (FDA) in 2001, 55 new PKIs have reached the market, and many inhibitors are currently being evaluated in clinical trials.
Colin Bournez +6 more
doaj +1 more source
Pattern matching and pattern discovery algorithms for protein topologies
, 2001 We describe algorithms for pattern matching and pattern learning in TOPS diagrams (formal descriptions of protein topologies). These problems can be reduced to checking for subgraph isomorphism and finding maximal common subgraphs in a restricted ...
Viksna, J +3 more
core +1 more source
The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases [PDF]
, 2016 The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to
Swiss Institute of Bioinformatics Members, SIB +1 more
core +1 more source
PROTEIN IDENTIFICATION USING SEQUENCE DATABASES
Scientific Journal of Astana IT University, 2020 The bottom-up proteomics approach (also known as the shotgun approach), based on the digestion of proteins in peptides and their sequencing using tandem mass spectrometry (MS/MS), has become widespread. The identification of peptides from the obtained MS/
Golenko Ye., A. Ismailova, Ye. Rais
doaj
BMC Bioinformatics, 2007 Background Each major protein database uses its own conventions when assigning protein identifiers. Resolving the various, potentially unstable, identifiers that refer to identical proteins is a major challenge.
Leinonen Rasko +8 more
doaj +1 more source
MedProDB: A database of Mediator proteins
Computational and Structural Biotechnology Journal, 2021 In the last three decades, the multi-subunit Mediator complex has emerged as the key component of transcriptional regulation of eukaryotic gene expression. Although there were initial hiccups, recent advancements in bioinformatics tools contributed significantly to in-silico prediction and characterization of Mediator subunits from several organisms ...
Rohan Bhardwaj +2 more
openaire +3 more sources
, 2010 The Protein Circular Dichroism Data Bank (PCDDB) is a public repository that archives and freely distributes circular dichroism (CD) and synchrotron radiation CD (SRCD) spectral data and their associated experimental metadata.
Klose, D.P. +11 more
core +1 more source
An Investigation of Alternatives to Transform Protein Sequence Databases to a Columnar Index Schema
Algorithms, 2021 Mass spectrometers enable identifying proteins in biological samples leading to biomarkers for biological process parameters and diseases. However, bioinformatic evaluation of the mass spectrometer data needs a standardized workflow and system that ...
Roman Zoun +7 more
doaj +1 more source
The Pfam protein families database [PDF]
Nucleic Acids Research, 2007 Pfam is a comprehensive collection of protein domains and families, represented as multiple sequence alignments and as profile hidden Markov models. The current release of Pfam (22.0) contains 9318 protein families. Pfam is now based not only on the UniProtKB sequence database, but also on NCBI GenPept and on sequences from selected metagenomics ...
Robert D. Finn +10 more
openaire +4 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source