Results 101 to 110 of about 8,887,267 (401)

Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide

Journal of Experimental & Clinical Cancer Research, 2019
Background Androgen receptor (AR) is expressed in approximately 70% of breast tumors. Recent studies increasingly support AR as a potential therapeutic target of AR-positive breast cancer.
Xiaohong Xia, Chuyi Huang, Yuning Liao, Yuan Liu, Jinchan He, Zhiqiang Guo, Lili Jiang, Xuejun Wang, Jinbao Liu, Hongbiao Huang   +9 more
doaj   +1 more source

Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells. [PDF]

, 2013
DNA-dependent protein kinase (DNA-PK) has an important role in the repair of DNA damage and regulates the radiation sensitivity of glioblastoma cells. The VCP (valosine-containing protein), a chaperone protein that regulates ubiquitin-dependent protein ...
Cao, L, Fei, X, Jiang, N, Kong, X, Larner, J, Mi, J, Qiu, Y, Shen, Y, Sheng, K, Sun, P   +9 more
core   +1 more source

Plasticity in binding confers selectivity in ligand induced protein degradation

Nature Chemical Biology, 2018
Heterobifunctional small-molecule degraders that induce protein degradation through ligase-mediated ubiquitination have shown considerable promise as a new pharmacological modality.
R. Nowak, S. DeAngelo, Dennis L. Buckley, Zhixiang He, K. Donovan, Jian An, N. Safaee, Mark P. Jedrychowski, Charles M. Ponthier, M. Ishoey, Tinghu Zhang, J. Mancias, N. Gray, J. Bradner, E. Fischer   +14 more
semanticscholar   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Bilirubin ameliorates murine atherosclerosis through inhibiting cholesterol synthesis and reshaping the immune system

Journal of Translational Medicine, 2022
Atherosclerosis is a chronic inflammatory disease caused mainly by lipid accumulation and excessive inflammatory immune response. Although the lipid-lowering and cardioprotective properties of bilirubin, as well as the negative relationship between ...
Guanmei Wen, Leyi Yao, Yali Hao, Jinheng Wang, Jinbao Liu   +4 more
doaj   +1 more source

Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding [PDF]

, 2009
The AU-rich element (ARE)-mediated mRNA-degradation activity of the RNA binding K-homology splicing regulator protein (KSRP) is regulated by phosphorylation of a serine within its N-terminal KH domain (KH1).
Briata, Paola, Díaz Moreno, Irene, Frenkiel, Thomas A., García Mayoral, María Flor, Gherzi, Roberto, Hollingworth, David, Howell, Steven, Kelly, Geoff, Martin, Stephen, Ramos, Andrés   +9 more
core   +2 more sources

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Follicle-stimulating hormone promotes EndMT in endothelial cells by upregulating ALKBH5 expression

Cellular & Molecular Biology Letters
Background The incidence of atherosclerosis markedly rises following menopause. Our previous findings demonstrated that elevated follicle-stimulating hormone (FSH) levels in postmenopausal women accelerate atherosclerosis progression. Plaque instability,
Ping Li, Yixiao Xiang, Jinzhi Wei, Xingyan Xu, Jiale Wang, Haowei Yu, Xiaosa Li, Huiping Lin, Xiaodong Fu   +8 more
doaj   +1 more source

Discovery of cellular regulation by protein degradation [PDF]

, 2008
What follows is a story of some of the lab’s adventures mentioned above, including the inventions of new biochemical and genetic methods. This account stems, in part, from previous descriptions of the early history of the Ub field (31,32).
Alagramam, Alexander Varshavsky, Alfageme, An, Aulner, Bachmair, Bachmair, Bakayev, Baker, Baker, Balzi, Barsoum, Bartel, Bartel, Blattes, Byrd, Chau, Ciechanover, Ciechanover, Ciechanover, Clarke, Coelho, D'Ambrosio, Damelin, Davydov, Demartino, Deming, Dinardo, Ditzel, Dohmen, Dohmen, Dohmen, Du, Dunnwald, Evans, Ferber, Finley, Finley, Finley, Fried, Garner, Geiss-Friedlander, Gisler, Glotzer, Goebl, Goldknopf, Gonda, Goto, Graciet, Grigoryev, Haering, Haggarty, Hanna, Harper, Hauf, Hershko, Hershko, Hershko, Hershko, Hershko, Hicke, Hochstrasser, Hochstrasser, Holm, Hou, Hu, Hu, Hu, Huang, Hunter, Inobe, Jentsch, Johnson, Johnson, Johnson, Johnsson, Johnsson, Kaiji, Kerppola, Kerscher, Kornberg, Kwon, Kwon, Kwon, Kwon, Kwon, Lee, Levinger, Levinger, Levinger, Levinger, Li, Lou, Lévy, Marunouchi, Matsumoto, McGrath, Meyer-Almes, Milutinovich, Minsky, Mogk, Mukhopadhyay, Nasmyth, Peters, Pickart, Rao, Roninson, Rubinsztein, Rumpf, Sasaki, Shamu, Sheng, Shintomi, Shrader, Skoufias, Soffer, Solomon, Steck, Strauss, Sundin, Sundin, Suzuki, Tarassov, Tasaki, Tasaki, Tobias, Tobias, Turner, Turner, Uemura, Uhlmann, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Wang, Wilkinson, Winter, Wittke, Woelk, Xia, Xie, Xie, Yi, Zenker, Özkaynak, Özkaynak   +158 more
core   +4 more sources