Results 101 to 110 of about 1,734,521 (378)

Follicle-stimulating hormone promotes EndMT in endothelial cells by upregulating ALKBH5 expression

Cellular & Molecular Biology Letters
Background The incidence of atherosclerosis markedly rises following menopause. Our previous findings demonstrated that elevated follicle-stimulating hormone (FSH) levels in postmenopausal women accelerate atherosclerosis progression. Plaque instability,
Ping Li, Yixiao Xiang, Jinzhi Wei, Xingyan Xu, Jiale Wang, Haowei Yu, Xiaosa Li, Huiping Lin, Xiaodong Fu   +8 more
doaj   +1 more source

Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide

Journal of Experimental & Clinical Cancer Research, 2019
Background Androgen receptor (AR) is expressed in approximately 70% of breast tumors. Recent studies increasingly support AR as a potential therapeutic target of AR-positive breast cancer.
Xiaohong Xia, Chuyi Huang, Yuning Liao, Yuan Liu, Jinchan He, Zhiqiang Guo, Lili Jiang, Xuejun Wang, Jinbao Liu, Hongbiao Huang   +9 more
doaj   +1 more source

Quantitative Cell-based Protein Degradation Assays to Identify and Classify Drugs That Target the Ubiquitin-Proteasome System [PDF]

, 2011
We have generated a set of dual-reporter human cell lines and devised a chase protocol to quantify proteasomal degradation of a ubiquitin fusion degradation (UFD) substrate, a ubiquitin ligase CRL2^(VHL) substrate, and a ubiquitin-independent substrate ...
Aghajan, Alvarez-Castelao, Bence, Beskow, Boyault, Boyault, Cao, Chou, Colson, Dantuma, DeLaBarre, Deshaies, Ding, Eldridge, Elofsson, Finley, Giaever, Golbik, Ito, Janiesch, Ju, Kane, Kimbrel, Lee, Lois, Milhazes, Müller, Nawrocki, Neuber, Noguchi, Ohh, Patel, Rabouille, Raymond J. Deshaies, Richly, Schrader, Soucy, Tsui-Fen Chou, Tsujimoto, Wang, Wang, Weissman, Yamamoto, Yamamoto, Yamamoto, Yang, Ye, Ye, Ye, Zhang, Zhang   +50 more
core   +3 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Combinatorial ubiquitin code degrades deubiquitylation-protected substrates

Nature Communications
Protein ubiquitylation is maintained by a dynamic balance of the conjugation and deconjugation of ubiquitin. It remains unclear how deubiquitylation-stabilized substrates are directed for degradation.
Mai Morita, Miyu Takao, Honoka Tokuhisa, Ryotaro Chiba, Shota Tomomatsu, Yoshino Akizuki, Takuya Tomita, Akinori Endo, Yasushi Saeki, Yusuke Sato, Fumiaki Ohtake   +10 more
doaj   +1 more source

Autophagy Induced by Proteasomal DUB Inhibitor NiPT Restricts NiPT-Mediated Cancer Cell Death

Frontiers in Oncology, 2020
Ubiquitin–proteasome system (UPS) and autophagy–lysosome pathway (ALP) are two major systems for protein quality control (PQC) in eukaryotic cells. Interconnectivity between these two pathways has been suggested, but the molecular detail of how they ...
Jinghong Chen, Jinghong Chen, Xin Chen, Dacai Xu, Li Yang, Li Yang, Zhenjun Yang, Qianqian Yang, Ding Yan, Peiquan Zhang, Du Feng, Jinbao Liu   +11 more
doaj   +1 more source

Prion degradation pathways: Potential for therapeutic intervention [PDF]

, 2015
Prion diseases are fatal neurodegenerative disorders. Pathology is closely linked to the misfolding of native cellular PrP(C) into the disease-associated form PrP(Sc) that accumulates in the brain as disease progresses. Although treatments have yet to be
Goold, R, McKinnon, C, Tabrizi, SJ
core   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

A new gold(I) complex-Au(PPh3)PT is a deubiquitinase inhibitor and inhibits tumor growthResearch in context

EBioMedicine, 2019
Background: Ubiquitin-proteasome system (UPS) is integral to cell survival by maintaining protein homeostasis, and its dysfunction has been linked to cancer and several other human diseases.
Xiaofen Li, Qingtian Huang, Huidan Long, Peiquan Zhang, Huabo Su, Jinbao Liu   +5 more
doaj  

Ubiquinol Reduces Muscle Wasting but Not Fatigue in Tumor-Bearing Mice [PDF]

, 2014
Purpose: Fatigue is the most common and distressing symptom reported by cancer patients during and after treatment. Tumor growth increases oxidative stress and cytokine production, which causes skeletal muscle wasting and cardiac dysfunction. The purpose
Clark, Yvonne, McCarthy, Donna O., Szalacha, Laura A., Wold, Loren E.   +3 more
core   +2 more sources