Results 111 to 120 of about 1,243,460 (313)

Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4A [PDF]

, 2014
Background The BAG6 complex resides in the cytosol and acts as a sorting point to target diverse hydrophobic protein substrates along their appropriate paths, including proteasomal degradation and ER membrane insertion.
Ewelina M Krysztofinska, Krysztofinska, EM, Darby, John F., Arjun Thapaliya, Maria R. Conte (664444), Isaacson Rivka L., Alfano, C, Bishop, David S., Peter J. Simpson (247964), Santiago Martínez-Lumbreras (206438), Conte, Maria R., Martinez-Lumbreras, S, High, S, Newran Sriskandarajah (664440), Leznicki, P, Rivka L. Isaacson (393277), Aline C Simon, Leznicki Pawel, Conte, Maria R; id_orcid, Thapaliya, Arjun, Caterina Alfano, Conte Maria R., Hale, Lisa R, High, Stephen; id_orcid, Simpson, PJ, Caterina Alfano (664443), Hale, Lisa R., Hale Lisa R., Pawel Leznicki (393272), Krysztofinska, Ewelina M, Simon, Aline C, Martínez-Lumbreras, Santiago, Newran Sriskandarajah, Sriskandarajah Newran, Bishop David S., Isaacson, Rivka L, Sriskandarajah, N, Aline C. Simon (664439), Ewelina M. Krysztofinska (393276), Bishop, DS, Simpson Peter J., Maria R Conte, Simpson, Peter J, Leznicki, Pawel, Darby, JF, John F. Darby (664438), David S. Bishop (664441), Thapaliya, A, Alfano Caterina, Hale, LR, Stephen High (20210), Peter J Simpson, Thapaliya Arjun, Conte, Maria R, Stephen High, Isaacson, RL, Arjun Thapaliya (664445), Krysztofinska Ewelina M., Martínez-Lumbreras Santiago, High Stephen, Darby John F., Lisa R Hale, Isaacson, Rivka L; id_orcid, John F Darby, Rivka L Isaacson, Lisa R. Hale (664442), Isaacson, Rivka L., Conte, MR, Simon Aline C., Darby, John F, Pawel Leznicki, Simon, AC, Simon, Aline C., David S Bishop, Santiago Martínez-Lumbreras, Krysztofinska, Ewelina M., Sriskandarajah, Newran, Bishop, David S, High, Stephen, Simpson, Peter J., Alfano, Caterina   +80 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Protein metabolism of prolific ewes during late gestation and early lactation

, 2001
Subject headings: protein / metabolism / ewesIntroduction of prolific crossbred ewes and a new protein evaluation system for ruminants, the DVE/OEB system, necessitate a reconsideration of ewe feeding strategies.
Sebek, L.B.J.
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Characterization of the novel Maurer's clefts protein MAHRP1 in "Plasmodium falciparum" [PDF]

, 2007
Plasmodium falciparum causes the worst form of human malaria and is responsible for 1-2 million deaths annually. A vaccine is not available and resistance to drugs is widespread.
Spycher, Anna Cornelia
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Translation and targeting of organellar proteins

, 2019
2
HWANG, INHWAN
core  

From Inhibition to Degradation: Targeting the Anti-apoptotic Protein Myeloid Cell Leukemia 1(MCL1)

, 2019
Here we show the development of heterobifunctional small molecules capable of selectively targeting MCL1 using a Proteolysis Targeting Chimera (PROTAC) methodology leading to successful degradation. We have confirmed the involvement of the
Ranjan, Maity, James, Papatzimas, Paola, Neri, Nizar J., Bahlis, Evgueni, Gorobets, Justin L., MacCallum, Darren, Derksen, Mir Ishruna, Muniyat   +7 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source