Results 111 to 120 of about 1,110,261 (265)

Mechanistic Insights into the Dual Directing Group-Mediated C–H Functionalization/Annulation via a Hydroxyl Group-Assisted MIII-MV‑MIII Pathway

ACS Omega, 2021
Huiying Xu, Mengyao Bian, Zhi Zhou, Hui Gao, Wei Yi   +4 more
doaj   +1 more source

Emerging biologic modalities for targeted protein degradation. [PDF]

J Biol Chem
Caldwell AG, Parmar H, Zhang X.
europepmc   +1 more source

Defining degradability landscape of protein degraders

Abstract Targeted protein degradation (TPD) is an emerging therapeutic modality. But how degradation efficacy is jointly determined by factors underlying this multi-step process is poorly understood. Here we present a succinct quantitative framework for modeling cellular mechanism of action of protein degraders, allowing for prediction of their
Olivier Elemento, Wei Du
openaire   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Revolutionizing protein degradation: Harnessing nanoparticles for PROTAC delivery. [PDF]

Mater Today Bio
Fan Y, Su J, Yang J, Guan X, Gong Y, Yang D, Qin A, Zhang L.   +7 more
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Serum RelB is correlated with renal fibrosis and predicts chronic kidney disease progression

Clinical and Translational Medicine, 2021
Donglin Sun, Ningxia Xie, Xi Wang, Wenquan Wu, Xiu‐Yong Li, Xiangqiu Chen, Guojun Qian, Cuifeng Li, Haohao Zhang, Yuhang Jiang, Deji Ye, Dandan Liu, Yiming Hu, Jingyao Wang, Weifeng Chen, Qiumei Zhao, Min Zeng, Junwei Zhang, Li Wang, Xiaoren Zhang   +19 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

PROTAC-based protein degradation: a window of opportunity for melanoma therapy. [PDF]

J Biomed Sci
Gentile G, D'Aguanno S, Di Martile M, Petricca A, Valentini E, Scalera S, Del Bufalo D.   +6 more
europepmc   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source