Results 111 to 120 of about 8,887,267 (401)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control [PDF]

, 2018
The deglycase and chaperone protein DJ-1 is pivotal for cellular oxidative stress responses and mitochondrial quality control. Mutations in PARK7, encoding DJ-1, are associated with early-onset familial Parkinson’s disease and lead to pathological ...
Abeti, Abou-Sleiman, Adam-Vizi, Alexis A. Robinson, Ariga, Banerjee, Ben-Nissan, Blackinton, Boland, Bonifati, Bonifati, Brenner-Lavie, Campanella, Canet-Avilés, Cannon, Carlo Rodolfo, Caterina Ferraina, Chen, Daniela Strobbe, Dauer, Dias, Duchen, D’Autréaux, East, Gatliff, Georgakopoulos, Giaime, Giordano, Görner, Harvey, Hulleman, Junn, Kahle, Kim, Kirsten Harvey, Lakshminarasimhan, Lara Rossi, Lücking, Maita, Martinat, Martinez-Vicente, Matic, Michelangelo Campanella, Moscovitz, Muller, Murphy, Narendra, Niki, Olzmann, Ono, Onyango, Paisán-Ruíz, Pankratz, Parker, Parsanejad, Polymeropoulos, Robert J. Harvey, Schon, Shendelman, Shinbo, Taira, Takahashi, Takahashi-Niki, Valente, Valerio de Biase, Waak, Wang   +66 more
core   +3 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Combinatorial ubiquitin code degrades deubiquitylation-protected substrates

Nature Communications
Protein ubiquitylation is maintained by a dynamic balance of the conjugation and deconjugation of ubiquitin. It remains unclear how deubiquitylation-stabilized substrates are directed for degradation.
Mai Morita, Miyu Takao, Honoka Tokuhisa, Ryotaro Chiba, Shota Tomomatsu, Yoshino Akizuki, Takuya Tomita, Akinori Endo, Yasushi Saeki, Yusuke Sato, Fumiaki Ohtake   +10 more
doaj   +1 more source

Targeting MYOF suppresses pancreatic ductal adenocarcinoma progression by inhibiting ILF3-LCN2 signaling through disrupting OTUB1-mediated deubiquitination of ILF3

Redox Biology
Pancreatic ductal adenocarcinoma (PDAC) is still a highly aggressive and fatal disease. The molecular mechanisms for PDAC progression are still not fully understood.
Zhihui Li, Jianlei Zhang, Jiang Yin, Wen Ma, Hongfan Liao, Lv Ling, Qingfeng Zou, Yabing Cao, Ying Song, Guopei Zheng, Xiaoye Hu, Guohua Yang, Nan Li   +12 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

MORC3, a component of PML nuclear bodies, has a role in restricting herpes simplex virus type 1 and human cytomegalovirus [PDF]

, 2016
We previously reported that MORC3, a protein associated with promyelocytic leukemia nuclear bodies (PML NBs), is a target of HSV-1 ICP0 mediated degradation.
Everett, Roger, Orr, Anne, Sloan, Elizabeth   +2 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Autophagy Induced by Proteasomal DUB Inhibitor NiPT Restricts NiPT-Mediated Cancer Cell Death

Frontiers in Oncology, 2020
Ubiquitin–proteasome system (UPS) and autophagy–lysosome pathway (ALP) are two major systems for protein quality control (PQC) in eukaryotic cells. Interconnectivity between these two pathways has been suggested, but the molecular detail of how they ...
Jinghong Chen, Jinghong Chen, Xin Chen, Dacai Xu, Li Yang, Li Yang, Zhenjun Yang, Qianqian Yang, Ding Yan, Peiquan Zhang, Du Feng, Jinbao Liu   +11 more
doaj   +1 more source

Advances in Protein Degradation [PDF]

SLAS Discovery, 2021
M Paola, Castaldi, Stewart L, Fisher
openaire   +2 more sources