Results 161 to 170 of about 1,243,460 (313)

A prize for protein degradation [PDF]

Nature Cell Biology, 2004
openaire   +2 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Towards the physiological role of ER quality control in an organismal context

, 2014
ER-associated degradation (ERAD) plays a pivotal role in cells with a highly active secretory apparatus, such as B lymphocytes, beta cells in the pancreas or hepatocytes.
König, P.A., Cellular Protein Chemistry
core  

Discovery of a KLHL41 Ligand for Muscle Specific Protein Degradation. [PDF]

Nat Commun
Yim J, Lee J, Kim S, Choi J, Yoon S, Cho H, Jung S, Yoo G, Lee S, Park H, Lee J, Park J.   +11 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

A special issue of Essays in Biochemistry on proteasome and protein degradation. [PDF]

Essays Biochem
Sahu I, Glickman MH.
europepmc   +1 more source

To degrade or not to degrade : protein handling by the proteasome

, 2010
The proteasome, a large multi-subunit protease that degrades proteins, must be able to distinguish between substrates deemed for destruction and accessory proteins that should be spared. The shuttle factor Rad23 operates in close proximity to the proteasome in order to deliver proteins for their degradation. While its cargo is efficiently degraded, the
openaire   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Serum RelB is correlated with renal fibrosis and predicts chronic kidney disease progression

Clinical and Translational Medicine, 2021
Donglin Sun, Ningxia Xie, Xi Wang, Wenquan Wu, Xiu‐Yong Li, Xiangqiu Chen, Guojun Qian, Cuifeng Li, Haohao Zhang, Yuhang Jiang, Deji Ye, Dandan Liu, Yiming Hu, Jingyao Wang, Weifeng Chen, Qiumei Zhao, Min Zeng, Junwei Zhang, Li Wang, Xiaoren Zhang   +19 more
doaj   +1 more source

Harnessing FBXO31 with Terminal Amide-Functionalized Molecules for Targeted Protein Degradation. [PDF]

J Am Chem Soc
Zhang C, Jin X, Zhou C, Jenkins MJ, Riha IA, Zhang X.   +5 more
europepmc   +1 more source