Results 191 to 200 of about 8,887,267 (401)

Effect of Kinds of Hay Given to Sheep on Rumen Degradability of Protein of Various Hays

, 1995
H. E. M. Kamel, Junjiro Sekine, Tetsuyuki SUGA, Ziro Morita   +3 more
openalex   +2 more sources

Targeted protein degradation: a promise for undruggable proteins.

Cell Chemical Biology, 2021
Kusal T. G. Samarasinghe, C. Crews
semanticscholar   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Supplementary Information from Identification and Selective Degradation of Neopeptide-Containing Truncated Mutant Proteins in the Tumors with High Microsatellite Instability

, 2023
Won Kyu Kim, Misun Park, Minhee Park, Yun Ji Kim, Nara Shin, Hyun Ki Kim, Kwon Tae You, Hoguen Kim   +7 more
openalex   +1 more source

Cancer therapies based on targeted protein degradation — lessons learned with lenalidomide

Nature Reviews Clinical Oncology, 2021
Max Jan, A. Sperling, B. Ebert
semanticscholar   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Male-Biased Cyp17a2 Orchestrates Antiviral Sexual Dimorphism in Fish via STING Stabilization and Viral Protein Degradation [PDF]

Long-Feng Lu, Bao-Jie Cui, Songtao Shi, Yangyang Wang, Can Zhang, Xiao Xu, Mingliang Tian, Zhiyang Li, Na Xu, Zhuo-Cong Li, Dandan Chen, Li Zhou, Gang Zhai, Zhan Yin, Shun Li   +14 more
openalex   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Mechanistic Insights into the Dual Directing Group-Mediated C–H Functionalization/Annulation via a Hydroxyl Group-Assisted MIII-MV‑MIII Pathway

ACS Omega, 2021
Huiying Xu, Mengyao Bian, Zhi Zhou, Hui Gao, Wei Yi   +4 more
doaj   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source