Results 201 to 210 of about 1,148,268 (263)

Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery

Advanced Functional Materials, EarlyView.
This work describes non‐PEGylated layered lipid nanoparticles (nonPEG LLNPs), a gene delivery platform that improves upon standard PEGylated LNPs via electrostatic adsorption of charged polymers. nonPEG LLNPs maintain colloidal stability under biological stresses, enhance circulation time, and mitigate accelerated blood clearance and hepatic ...
Namita Nabar, Deeksha Kumaresh, Eduardo Nombera Bueno, Mae Pryor, Paula T. Hammond   +4 more
wiley   +1 more source

Cuscuta chinensis Lam. extract alleviates ovariectomy-induced osteoporosis by inhibiting VCP-mediated METTL3 protein degradation. [PDF]

J Mol Histol
Jiang H, Ma L, Liu Y, Li M, Sun J, Ma J.
europepmc   +1 more source

Acyclic Glutarimide PROTAC Precursors Enable Controlled Protein Degradation and Expand Cereblon Ligand Space. [PDF]

ACS Med Chem Lett
Renner AC, Kargbo RB.
europepmc   +1 more source

The application of drug delivery systems based on targeted protein degradation chimeras in disease treatment strategies. [PDF]

J Nanobiotechnology
Lin W, Qiao E, Wang Z, Tang C, Li C, Lu J.   +5 more
europepmc   +1 more source

Structural plasticity of the membrane-bound protein degradation assembly supports bacterial adaptation to stress. [PDF]

Cell Rep
Iqbal N, Keller S, Ghanbarpour A.
europepmc   +1 more source

Cell type-specific spatiotemporal control of GFP-tagged protein degradation in mice. [PDF]

J Cell Biol
Prado-Mantilla A, Sheheen J, Underwood J, Lechler T.   +3 more
europepmc   +1 more source

Tuning the open-close equilibrium of Cereblon with small molecules influences protein degradation

O’Connor S, Rutter ZJ, Cowan AD, Zeeb M, Binder F, Cao Y, Chakraborti S, Djukic S, Geist L, Hogg E, Kidd G, Krumb M, Langer S, Schmidt D, Martin L, McCrory EH, Padroni G, Puoti I, Simpson L, Sturbaut M, Crozier L, Vetma V, Zhang Q, McAulay K, Theis T, Ciulli A.   +25 more
europepmc   +1 more source

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Molecular Machines for Protein Degradation

ChemBioChem, 2005
AbstractOne of the most precisely regulated processes in living cells is intracellular protein degradation. The main component of the degradation machinery is the 20S proteasome present in both eukaryotes and prokaryotes. In addition, there exist other proteasome‐related protein‐degradation machineries, like HslVU in eubacteria.
Matthias Bochtler, Michael Groll, Hans Brandstetter   +2 more
exaly   +4 more sources

Catching proteins for degradation

Science, 2023
A ubiquitin-independent pathway targets nuclear proteins to the ...
Charlotte M, Schilling, Eilika, Weber-Ban   +1 more
openaire   +2 more sources

Targeted protein degradation and the enzymology of degraders

Current Opinion in Chemical Biology, 2018
Targeted protein degradation is an emerging strategy for drug discovery that employs small molecules to catalyze the ubiquitination of target proteins, ultimately causing their degradation by the proteasome. Current degrader designs employ hetero-bivalent molecules to recruit E3 ubiquitin ligases such as VHL, Cereblon, and the IAPs to the target ...
Stewart L, Fisher, Andrew J, Phillips
openaire   +2 more sources