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Eukaryotic protein degradation
Current Opinion in Cell Biology, 1990Early studies of intracellular protein degradation revealed several properties common to all types of eukaryotic cells. Cellular proteins are continuously turning over and measurements of the fate of individual proteins have shown them to have widely differing half-lives (ranging from a few minutes to many days).
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Monitoring protein degradation
2002Publisher Summary Protein degradation processes can be divided in two categories: bulk degradation and selective degradation of specific proteins. Individual protein species can differ in stability by several orders of magnitude. Constitutive fast turnover of a protein allows the rapid modulation of its concentration in response to changes in its ...
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Nature Chemical Biology
In May 2024, ‘Protein Degradation in Focus’, a special symposium aimed at bringing together scientists in the targeted protein degradation (TPD) field, was held in Dundee, UK. David Zollman and Kirsten McAulay report on the topics discussed and the exciting outlook for science in the TPD space.
David Zollman, Kirsten McAulay
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In May 2024, ‘Protein Degradation in Focus’, a special symposium aimed at bringing together scientists in the targeted protein degradation (TPD) field, was held in Dundee, UK. David Zollman and Kirsten McAulay report on the topics discussed and the exciting outlook for science in the TPD space.
David Zollman, Kirsten McAulay
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Mechanisms of substrate processing during ER-associated protein degradation
Nature Reviews Molecular Cell Biology, 2023Thomas Sommer +2 more
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BacPROTACs mediate targeted protein degradation in bacteria
Cell, 2022Tim Clausen, Robert Kurzbauer
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Protein degradation in the lysosome
Biochemical Society Transactions, 1985H, Glaumann +4 more
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Parasitic modulation of host development by ubiquitin-independent protein degradation
Cell, 2021Weijie Huang +2 more
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Targeted protein degradation: A promise for undruggable proteins
Cell Chemical Biology, 2021Kusal Samarasinghe, Craig M Crews
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