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Eukaryotic protein degradation

Current Opinion in Cell Biology, 1990
Early studies of intracellular protein degradation revealed several properties common to all types of eukaryotic cells. Cellular proteins are continuously turning over and measurements of the fate of individual proteins have shown them to have widely differing half-lives (ranging from a few minutes to many days).
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Monitoring protein degradation

2002
Publisher Summary Protein degradation processes can be divided in two categories: bulk degradation and selective degradation of specific proteins. Individual protein species can differ in stability by several orders of magnitude. Constitutive fast turnover of a protein allows the rapid modulation of its concentration in response to changes in its ...
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Protein Degradation in Focus

Nature Chemical Biology
In May 2024, ‘Protein Degradation in Focus’, a special symposium aimed at bringing together scientists in the targeted protein degradation (TPD) field, was held in Dundee, UK. David Zollman and Kirsten McAulay report on the topics discussed and the exciting outlook for science in the TPD space.
David Zollman, Kirsten McAulay
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Protein degradation in yeast

Biochemical Society Transactions, 1987
U, Teichert   +3 more
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Protein Degradation

The Biomedical & Life Sciences Collection, 2007
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Mechanisms of substrate processing during ER-associated protein degradation

Nature Reviews Molecular Cell Biology, 2023
Thomas Sommer   +2 more
exaly  

BacPROTACs mediate targeted protein degradation in bacteria

Cell, 2022
Tim Clausen, Robert Kurzbauer
exaly  

Protein degradation in the lysosome

Biochemical Society Transactions, 1985
H, Glaumann   +4 more
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Parasitic modulation of host development by ubiquitin-independent protein degradation

Cell, 2021
Weijie Huang   +2 more
exaly  

Targeted protein degradation: A promise for undruggable proteins

Cell Chemical Biology, 2021
Kusal Samarasinghe, Craig M Crews
exaly  

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