Results 231 to 240 of about 1,849,171 (299)

Recent Advances in the Development of Pro-PROTAC for Selective Protein Degradation. [PDF]

Pharmaceutics
Hakem F, Abdelwaly A, Alshaman R, Alattar A, Alanazi FE, Zaitone SA, Helal MA.   +6 more
europepmc   +1 more source

Multiplex Modular Nanorobotic Systems with Catalytic Activity under Magnetic Navigation

Advanced Functional Materials, EarlyView.
We present modular nanorobots composed of a magnetic propulsion module and different extension modules carrying functional activities, assembled via DNA base pairing. The system integrates propulsion, optical tracking, enzymatic catalysis, and cell docking in a programmable manner.
Voichita Mihali, Xinan Huang, Lucie Motyckova, Nicolas Moreno Gomez, Michal Skowicki, Cora‐Ann Schoenenberger, Peer Fischer, Cornelia G. Palivan   +7 more
wiley   +1 more source

Synthetic protein degradation circuits using programmable cleavage and ligation by Sortase A. [PDF]

Nat Commun
Yang HK, Muthukumar PK, Chen W.
europepmc   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Antioxidant Natural Compounds Integrated with Targeted Protein Degradation: A Multi-Modal Strategy for Alzheimer's Disease Therapy. [PDF]

Antioxidants (Basel)
Singh DD, Yadav DK, Shin D.
europepmc   +1 more source

Multi‐Responsive Dendrimer‐Hyaluronic Acid Hydrogel With Lubricating and Immunoregulatory Functions for Synergistic Osteoarthritis Therapy

Advanced Functional Materials, EarlyView.
A hydrogel with dynamic cross‐links was formed by cross‐linking hyaluronic acid with curcumin‐preloaded, phenylboronic acid‐modified poly(amidoamine) dendrimers. This hydrogel exhibited excellent injectability and self‐healing ability, enabling controlled Cur release in response to low pH, high reactive oxygen species (ROS) generation, or mechanical ...
Junjie Liu, Mengsi Zhan, Haoyu Huang, Jianhong Wang, Cheng Ni, Xiaojun Zhou, Hannah Küttner, Cong Song, Xiangyang Shi, Andrij Pich   +9 more
wiley   +1 more source

Proof of concept: targeted protein degradation of the stress granules component G3BP1 as an antiviral strategy against norovirus infection. [PDF]

Antimicrob Agents Chemother
Echavarria-Consuegra L, Goodfellow I.
europepmc   +1 more source

Acetylation: a new target for protein degradation in cancer. [PDF]

Trends Cancer
Crawford CEW, Burslem GM.
europepmc   +1 more source

Metabolomic Profiles Associated With Difference in Muscle Protein Degradation Between Fast- and Slow-Growing Chicks During the Neonatal Period. [PDF]

Anim Sci J
Shimamoto S, Katayama H, Ijiri D, Fujimura S, Nakashima K, Ishihara S, Tomonaga S, Ohtsuka A, Kamimura M.   +8 more
europepmc   +1 more source

Male-biased Cyp17a2 orchestrates antiviral sexual dimorphism in fish via STING stabilization and viral protein degradation. [PDF]

Elife
Lu LF, Cui BJ, Shi SC, Wang YY, Zhang C, Xu X, Tian MZ, Li ZQ, Xu N, Li ZC, Chen DD, Zhou L, Zhai G, Yin Z, Li S.   +14 more
europepmc   +1 more source