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Correction: Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation. [PDF]
RSC Chem BiolBond MJ, Crews CM.
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<i>Lactobacillus gasseri</i> CBT LGA2 alleviates muscle protein degradation and inflammation in immobilization-induced mouse. [PDF]
Front MicrobiolJang JH, Lim SJ, Choi HS, Lim S, Oh NS.
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The contribution of native protein complexes to targeted protein degradation
Glennie L +8 more
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Molecular Machines for Protein Degradation
ChemBioChem, 2005AbstractOne of the most precisely regulated processes in living cells is intracellular protein degradation. The main component of the degradation machinery is the 20S proteasome present in both eukaryotes and prokaryotes. In addition, there exist other proteasome‐related protein‐degradation machineries, like HslVU in eubacteria.
Michael Groll +2 more
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Catching proteins for degradation
Science, 2023A ubiquitin-independent pathway targets nuclear proteins to the ...
Charlotte M, Schilling +1 more
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Targeted protein degradation and the enzymology of degraders
Current Opinion in Chemical Biology, 2018Targeted protein degradation is an emerging strategy for drug discovery that employs small molecules to catalyze the ubiquitination of target proteins, ultimately causing their degradation by the proteasome. Current degrader designs employ hetero-bivalent molecules to recruit E3 ubiquitin ligases such as VHL, Cereblon, and the IAPs to the target ...
Stewart L, Fisher, Andrew J, Phillips
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Protein folding and degradation in bacteria:¶To degrade or not to degrade? That is the question
Cellular and Molecular Life Sciences, 2002In Escherichia coli protein quality control is carried out by a protein network, comprising chaperones and proteases. Central to this network are two protein families, the AAA+ and the Hsp70 family. The major Hsp70 chaperone. DnaK, efficiently prevents protein aggregation and supports the refolding of damaged proteins. In a special case, DnaK, together
Dougan, David A. +2 more
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Protein degradation in signaling
Current Opinion in Plant Biology, 2000Recent studies have linked proteolysis by the ubiquitin/proteasome pathway to a variety of signaling pathways in higher plants. These links were uncovered by characterization of mutants altered in signaling or by targeted disruption of components of the proteolytic pathway. Significant advances have recently revealed connections between proteolysis and
J, Callis, R D, Vierstra
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Experimental Gerontology, 2005
Continuous turnover of intracellular proteins is essential for the maintenance of cellular homeostasis and for the regulation of multiple cellular functions. The first reports showing a decrease in total rates of protein degradation with age are dated more than 50 years ago, when the major players in protein degradation where still to be discovered ...
Marta, Martinez-Vicente +2 more
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Continuous turnover of intracellular proteins is essential for the maintenance of cellular homeostasis and for the regulation of multiple cellular functions. The first reports showing a decrease in total rates of protein degradation with age are dated more than 50 years ago, when the major players in protein degradation where still to be discovered ...
Marta, Martinez-Vicente +2 more
openaire +2 more sources