Results 201 to 210 of about 1,110,261 (265)

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

Targeted protein degradation in Escherichia coli using CLIPPERs. [PDF]

EMBO Rep
Izert-Nowakowska MA, Klimecka MM, Antosiewicz A, Wróblewski K, Kowalski JJ, Bandyra KJ, Góral T, Kmiecik S, Serwa RA, Górna MW.   +9 more
europepmc   +1 more source

Protein degradation in human skeletal muscle: advancing postmortem interval estimation under natural outdoor conditions. [PDF]

Int J Legal Med
Holzer E, Harris JC, Brüderl J, Helm K, Flachberger L, Pratt EPS, Steinbacher P, Monticelli F, Pittner S.   +8 more
europepmc   +1 more source

Dual functionality of MDM2 in PROTACs expands the horizons of targeted protein degradation. [PDF]

Biomark Res
Zhao J, Chen H, Liang C.
europepmc   +1 more source

Nanoparticle-Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology. [PDF]

Angew Chem Int Ed Engl
Baker AG, Ho APT, Itzhaki LS, Fruk L.
europepmc   +1 more source

Recent advances in glutarimide chemistry for cereblon-mediated targeted protein degradation: developments in synthesis and diversification. [PDF]

RSC Med Chem
Ba X, Dehghany M, Mortensen DS, Holmberg-Douglas N.   +3 more
europepmc   +1 more source

De novo designed protein guiding targeted protein degradation. [PDF]

Nat Commun
Li Z, Qiao G, Wang X, Wang M, Cheng J, Hu G, Li X, Wu J, Liu J, Gao C, Liu L.   +10 more
europepmc   +1 more source

Inducing TRIB2 Targeted Protein Degradation to Reverse Chemoresistance in Acute Myeloid Leukaemia

Rigby E, Narayanan A, Kania E, Harris JA, Williams J, Zhang B, Liu L, Richmond L, Zhou F, Ding K, Carmody RJ, Eyers PA, Keeshan K.   +12 more
europepmc   +1 more source

The contribution of native protein complexes to targeted protein degradation

Glennie L, Curnutt N, Cartwright T, Dunbar K, Chatelier BL, Wood NT, Macartney TJ, Woo CM, Sapkota GP.   +8 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Targeted protein degradation

Current Opinion in Chemical Biology, 2005
The ubiquitin-proteasome pathway plays a major role in cellular protein destruction and regulates fundamental cellular processes such as the cell cycle, cell signaling, and development. By altering the substrate recognition of ubiquitin-protein ligases, their robust proteolytic activity can be re-directed to recruit and accelerate the degradation of ...
openaire   +2 more sources