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Mechanisms of substrate processing during ER-associated protein degradation
Nature reviews. Molecular cell biology, 2023J. Christianson, E. Jarosch, T. Sommer
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Extracellular targeted protein degradation: an emerging modality for drug discovery
Nature reviews. Drug discovery, 2023James A. Wells, Kaan Kumru
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Monitoring protein degradation
2002Publisher Summary Protein degradation processes can be divided in two categories: bulk degradation and selective degradation of specific proteins. Individual protein species can differ in stability by several orders of magnitude. Constitutive fast turnover of a protein allows the rapid modulation of its concentration in response to changes in its ...
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Light-induced protein degradation with photo-caged PROTACs.
Journal of the American Chemical Society, 2019Induction of protein degradation is emerging as a powerful strategy to modulate protein functions and alter cellular signaling pathways. Proteolysis-targeting chimeras (PROTACs) have been used to degrade a range of diverse proteins in vitro and in vivo ...
Gang Xue +4 more
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Molecular Machines for Protein Degradation
ChemBioChem, 2005AbstractOne of the most precisely regulated processes in living cells is intracellular protein degradation. The main component of the degradation machinery is the 20S proteasome present in both eukaryotes and prokaryotes. In addition, there exist other proteasome‐related protein‐degradation machineries, like HslVU in eubacteria.
Michael, Groll +4 more
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Nature Chemical Biology
In May 2024, ‘Protein Degradation in Focus’, a special symposium aimed at bringing together scientists in the targeted protein degradation (TPD) field, was held in Dundee, UK. David Zollman and Kirsten McAulay report on the topics discussed and the exciting outlook for science in the TPD space.
David Zollman, Kirsten McAulay
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In May 2024, ‘Protein Degradation in Focus’, a special symposium aimed at bringing together scientists in the targeted protein degradation (TPD) field, was held in Dundee, UK. David Zollman and Kirsten McAulay report on the topics discussed and the exciting outlook for science in the TPD space.
David Zollman, Kirsten McAulay
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RAT MYOCARDIAL PROTEIN DEGRADATION
Clinical and Experimental Pharmacology and Physiology, 1981SUMMARY1. Myocardial protein degradation rates were determined by following tyrosine release from rat isolated left hemi‐atria in vitro.2. After two 20 min preincubations the rate of tyrosine release from hemi‐atria was constant for 4 h.3. Skeletal muscle protein degradation was determined by following tyrosine release from rat isolated hemi‐diaphragm (
J H, Steer, B E, Hopkins
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Regulating protein degradation by ubiquitination
Immunology Today, 1997Abstract Ubiquitination and ubiquitin-mediated protein degradation play key roles in many cellular processes, including cell-cycle progression, gene vanscription and signal transduction. Dysregulated ubiquitination contributes to malignant transformation, and oncogenic counterparts of normally ubiquitinated protects are resistant to ubiquitination ...
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Protein degradation in the lysosome
Biochemical Society Transactions, 1985H, Glaumann +4 more
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