Results 71 to 80 of about 1,856,978 (353)
Proof of concept of NX‐2127, a first‐in‐class Bruton's Tyrosine Kinase (BTK) dual‐targeted protein degrader with immunomodulatory activity, in patients with DLBCL [PDF]
, 2023 Alexey V. Danilov +8 more
openalex +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The ubiquitin-proteasome pathway in Huntington's disease. [PDF]
, 2008 The accumulation of mutant protein is a common feature of neurodegenerative disease. In Huntington's disease, a polyglutamine expansion in the huntingtin protein triggers neuronal toxicity.
Finkbeiner, Steven, Mitra, Siddhartha
core +2 more sources
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Frontiers in Pharmacology, 2020 Metabolic reprogramming is a cancer hallmark. Although the reprogramming of central carbon has been well documented, the role of sulfur metabolism has been largely overlooked.
Ximing Zhang +7 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2023 Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Identification of the underlying mechanism of HCC progression and exploration of new therapeutic drugs are urgently needed. Here, a compound library consisting of 419 FDA-approved
Xiang-Peng Tan +11 more
doaj +1 more source
Stepping up protein degradation [PDF]
Proceedings of the National Academy of Sciences, 2018 Cryoelectron microscopy (cryo-EM) has revolutionized knowledge of protein remodeling and unfolding by ATPases of the AAA (ATPases associated with various cellular activities) family, including those associated with energy-dependent proteolysis. A study in PNAS by Majumder et al.
openaire +2 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide
Journal of Experimental & Clinical Cancer Research, 2019 Background Androgen receptor (AR) is expressed in approximately 70% of breast tumors. Recent studies increasingly support AR as a potential therapeutic target of AR-positive breast cancer.
Xiaohong Xia +9 more
doaj +1 more source
Toxic Protein Degradation Products
Experimental Biology and Medicine, 1959 SummaryToxic polypeptides, similar to those obtained by Vaughan(1), have been prepared by treatment of certain proteins with boiling 2% ethanolic sodium hydroxide. These substances are soluble in water and in ethanol, are capable of dialyzing through a cellophane membrane and have been shown to be a mixture of essentially basic polypeptides of similar ...
H, RINDERKNECHT, C, NIEMANN
openaire +2 more sources