Results 61 to 70 of about 1,243,460 (313)
Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner [PDF]
, 2014 The transcription factor HIF-1α is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF-1α is frequently deregulated in cancer and correlates with poor patient prognosis.
Anja Bremm +9 more
core +1 more source
Inhibition of EGFR signaling with Spautin-1 represents a novel therapeutics for prostate cancer
Journal of Experimental & Clinical Cancer Research, 2019 Background Prostate cancer (PCa) remains a challenge worldwide. Due to the development of castration-resistance, traditional first-line androgen deprivation therapy (ADT) became powerlessness.
Yuning Liao +8 more
doaj +1 more source
Advanced Science, 2023 YTH domain family 2 (YTHDF2) is the first identified N6‐methyladenosine (m6A) reader that regulates the status of mRNA. It has been reported that overexpressed YTHDF2 promotes carcinogenesis; yet, its role in hepatocellular carcinoma (HCC) is elusive ...
Yuning Liao +11 more
doaj +1 more source
Regulation of BRCA1 by protein degradation [PDF]
Oncogene, 1999 BRCA1, a tumor suppressor protein implicated in hereditary forms of breast and ovarian cancer, is transcriptionally regulated in a proliferation-dependent manner. In this study, we demonstrate a substantial role for proteolysis in regulating the BRCA1 steady-state protein level in several cell lines. N-acetyl-leu-leu-norleucinal (ALLN), an inhibitor of
M V, Blagosklonny +5 more
openaire +2 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Reversible Spatiotemporal Control of Induced Protein Degradation by Bistable photoPROTACs
, 2019 Off-target effects are persistent issues of modern inhibition-based therapies. By merging the strategies of photopharmacology and small molecule degraders, we introduce a novel concept for persistent spatiotemporal control of induced protein degradation ...
Patrick, Pfaff +3 more
core +1 more source
Degradation of vasopressin precursor and pathogenic mutants in diabetes insipidus [PDF]
, 2007 The nonapeptide hormone, arginine vasopressin, plays a decisive role in the regulation of fluid balance by reducing free water clearance through reabsorption of water in the renal collecting ducts.
Friberg, Michael
core +1 more source
Protein degradation systems in platelets [PDF]
Thrombosis and Haemostasis, 2013 SummaryProtein synthesis and degradation are essential processes that allow cells to survive and adapt to their surrounding milieu. In nucleated cells, the degradation and/or cleavage of proteins is required to eliminate aberrant proteins. Cells also degrade proteins as a mechanism for cell signalling and complex cellular functions.
B F, Kraemer, A S, Weyrich, S, Lindemann
openaire +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
An investigation of mono-chlorophenol degradation and the bioaugmentation of activated sludge by two pseudomonas putida species [PDF]
, 2006 The degradation of all three mono-chlorophenols by two Pseudomonas putida species, A(a) and CPI, was investigated Pseudomonas putida A(a) metabolised 4-chlorophenol to completion via the meta-cleavage pathway but the degradation of 2- and 3- chlorophenol
McLaughlin, Henry
core