Results 41 to 50 of about 1,243,460 (313)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Multiple C-terminal Lysine residues target p53 for ubiquitin-proteasome-mediated degradation

, 2000
This work was supported by the Medical Research Council, the Biotechnology and Biological Research Council, and the Cancer Research Campaign. D.P.L. is a Gibb fellow of the Cancer Research Campaign.In normal cells, p53 is maintained at a low level by ...
Lain, Sonia, Lane, David P., T. Hay, Ronald, Hay, Ronald Thomas, Rodriguez, Manuel S, Desterro, Joana M P   +6 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Ubiquitin-specific protease USP25 functions in endoplasmic reticulum-associated degradation

, 2012
Endoplasmic Reticulum (ER)-associated degradation (ERAD) discards abnormal proteins synthesized in the ER. Through coordinated actions of ERAD components, misfolded/anomalous proteins are recognized, ubiquitinated, extracted from the ER and ultimately ...
Amanda Denuc, Marfany Gemma, Denuc Isern, Amanda, Todi, S. V., Burr, A. A., Gemma Marfany, Blount Jessica R., Sokol V Todi, Todi Sokol V., Marfany i Nadal, Gemma, Jessica R Blount, Denuc Amanda, Blount, J. R., Aaron A Burr, Burr Aaron A.   +14 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Hempseed cake as a protein feed for ruminants [PDF]

, 2010
Increasing the use of locally produced protein feeds in ruminant production systems in northern Europe would be a valuable development. Hemp (Cannabis sativa L.) can be cultivated at high latitudes and cold-pressing the seeds to extract the oil produces ...
Karlsson, Linda
core  

PGRP-SC–mediated innate immune memory against pathogenic bacteria in Drosophila

hLife
Trained immunity is essential for innate immune cells to retain a memory of previously encountered pathogens, strengthening the hosts’ response against these pathogens. However, the mechanisms governing trained immunity have not been well elucidated.
Zihao Deng, Jiazhen Luo, Yufu Zhang, Chen Li, Shixin Deng, Jiazhi He, Zihao He, Wenqi Wu, Renjie Jiao, Jiyong Liu   +9 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation [PDF]

, 2014
Arsenic is a clinically effective treatment for acute promyelocytic leukaemia (APL) in which the promyelocytic leukaemia (PML) protein is fused to retinoic receptor alpha (RARα).
Hands, K.J., Hay, Ronald T., Everett, R.D., Hay, R.T., Hands, Katherine J., Cuchet-Lourenco, Delphine, Everett, Roger D., Cuchet-Lourenco, D.   +7 more
core   +1 more source

Intrinsic signaling pathways modulate targeted protein degradation

Nature Communications
Targeted protein degradation is a groundbreaking modality in drug discovery; however, the regulatory mechanisms are still not fully understood. Here, we identify cellular signaling pathways that modulate the targeted degradation of the anticancer target ...
Yuki Mori, Yoshino Akizuki, Rikuto Honda, Miyu Takao, Ayaka Tsuchimoto, Sota Hashimoto, Hiroaki Iio, Masakazu Kato, Ai Kaiho-Soma, Yasushi Saeki, Jun Hamazaki, Shigeo Murata, Toshikazu Ushijima, Naoko Hattori, Fumiaki Ohtake   +14 more
doaj   +1 more source