Results 21 to 30 of about 1,243,460 (313)

XBP1‐elicited environment by chemotherapy potentiates repopulation of tongue cancer cells by enhancing miR‐22/lncRNA/KAT6B‐dependent NF‐κB signalling

Clinical and Translational Medicine, 2023
Background Tumour repopulation initiated by residual tumour cells in response to cytotoxic therapy has been described clinically and biologically, but the mechanisms are unclear.
Xiaoting Jia, Ge Wang, Lihong Wu, Hao Pan, Li Ling, Jianlei Zhang, Qingquan Wen, Jie Cui, Zhimin He, Bin Qi, Shuxu Zhang, Liyun Luo, Guopei Zheng   +12 more
doaj   +1 more source

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation [PDF]

, 2020
Hop/Stip1/Sti1 is thought to be essential as a co-chaperone to facilitate substrate transfer between the Hsp70 and Hsp90 molecular chaperones. Despite this proposed key function for protein folding and maturation, it is not essential in a number of ...
Sadian, Y., Bernasconi, L., Luengo, T.M., Bauer, C., Koopman, Margreet B., Cellular Protein Chemistry, Weidenauer, L., Rüdiger, Stefan G. D., Echeverría, Pablo C., Sub Cellular Protein Chemistry, Villemin, M., Quadroni, Manfredo, Weidenauer, Lorenz, Pieters, E.C., Sadian, Yashar, Bhattacharya, Kaushik, Luengo, Tania Morán, Quadroni, M., Wider, Diana, Pieters, Ellis C., Bhattacharya, K., Koopman, M.B., Picard, Didier, Villemin, Matthieu, Echeverría, P.C., Rüdiger, SGD, Bauer, Christoph Ruediger, Bauer, Christoph, Picard, D., Rüdiger, Stefan G.D., Echeverria, Pablo, Bernasconi, Lilia, Wider, D.   +32 more
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Peptides/Proteins Encoded by Non-coding RNA: A Novel Resource Bank for Drug Targets and Biomarkers

Frontiers in Pharmacology, 2018
Non-coding RNAs (ncRNAs) are defined as RNA molecules that do not encode proteins, but recent evidence has proven that peptides/proteins encoded by ncRNAs do indeed exist and usually contain less than 100 amino acids.
Song Zhu, Song Zhu, Jizhong Wang, Jizhong Wang, Yutian He, Yutian He, Nan Meng, Nan Meng, Guang-Rong Yan, Guang-Rong Yan   +9 more
doaj   +1 more source

Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and in HuH7 cells.

, 2013
Signal transduction modulates expression and activity of cholesterol transporters. We recently demonstrated that the Ras/mitogen-activated protein kinase (MAPK) signaling cascade regulates protein stability of Scavenger Receptor BI (SR-BI) through ...
Enrich Bastús, Carles, Enrich Carlos, Karen Cecilia Chan, Monira Hoque, Darabi, Masoud, Reverter Martín, Meritxell, Hoque, Monira, Rentero Alfonso, Carles, Meritxell Reverter, Rentero Carles, Melanie Manetsch, Masoud Darabi, Mulay, Vishwaroop, Peta Wood, Grewal Thomas, Álvarez-Guaita, Anna, Heeren, Joerg, Anna Alvarez-Guaita, Kerry-Anne Rye, Darabi Masoud, Rye Kerry-Anne, Chan, Karen Cecilia, Manetsch, Melanie, Mulay Vishwaroop, Manetsch Melanie, Heeren Joerg, Carlos Enrich, Cairns, Rose, Reverter Meritxell, Joerg Heeren, Carles Rentero, Vishwaroop Mulay, Rose Cairns, Wood Peta, Wood, Peta, Grewal, Thomas, Rye, Kerry-Anne, Chan Karen Cecilia, Álvarez-Guaita Anna, Thomas Grewal, Hoque Monira, Cairns Rose   +41 more
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Selective degradation of AR-V7 to overcome castration resistance of prostate cancer

Cell Death and Disease, 2021
Androgen receptor splice variant 7 (AR-V7), a form of ligand-independent and constitutively activating variant of androgen receptor (AR), is considered as the key driver to initiate castration-resistant prostate cancer (CRPC).
Yuan Liu, Cuifu Yu, Zhenlong Shao, Xiaohong Xia, Tumei Hu, Weiyao Kong, Xiaoyue He, Wenshuang Sun, Yuanfei Deng, Yuning Liao, Hongbiao Huang   +10 more
doaj   +1 more source

Native Mass Spectrometry: Insights and Opportunities for Targeted Protein Degradation

, 2023
Native mass spectrometry (nMS) is one of the most powerful biophysical methods for the direct observation of noncovalent protein interactions with both small molecules and other proteins.
Sternicki, Louise M, Poulsen, Sally-Ann
core   +1 more source

Deficient DNASE1L3 facilitates neutrophil extracellular traps‐induced invasion via cyclic GMP‐AMP synthase and the non‐canonical NF‐κB pathway in diabetic hepatocellular carcinoma

Clinical & Translational Immunology, 2022
Objective Diabetic hepatocellular carcinoma (HCC) patients have high mortality and metastasis rates. Diabetic conditions promote neutrophil extracellular traps (NETs) generation, which mediates HCC metastasis and invasion.
Na Li, Xue Zheng, Mianrong Chen, Li Huang, Li Chen, Rui Huo, Xiaotong Li, Yucan Huang, Mingwen Sun, Suiqing Mai, Zhuoyi Wu, Hui Zhang, Jinbao Liu, Chun‐tao Yang   +13 more
doaj   +1 more source

Ube2m-Mediated P27kip1 Degradation in Gemcitabine Cytotoxicity

, 2012
Gemcitabine 2-deoxy-2, 2-difluorocytidine; Gem is a nucleoside anti- metabolite and is commonly used for treating various human cancers including human bladder carcinoma. Gemcitabine not only functions as a suicide nucleoside analog but also inhibits DNA
黃阿梅;高毓婷;林秉毅;周季賢;胡惠婷;劉界元;侯自銓;蒲永孝, HUANG, A-MEI;KAO, YU-TING;LIN, PIN-YI;CHOU, CHI-HSIEN;HU, HUEI-TING;LIOU, JIEH-YUAN;HOUR, TZYH-CHYUAN;PU, YEONG-SHIAU   +1 more
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USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling [PDF]

, 2014
Protein kinase ALK3/BMPR1A mediates bone morphogenetic protein (BMP) signalling through phosphorylation and activation of SMADs 1/5/8. SMAD6, a transcriptional target of BMP, negatively regulates the BMP pathway by recruiting E3 ubiquitin ligases and ...
Bruce, David, Smith, James C., Dingwell, Kevin S., Cummins, Timothy D., Ewan, Richard, Macartney, Thomas, Al-Salihi, Mazin A., Weidlich, Simone, Vogt, Janis, Herhaus, Lina, Sapkota, Gopal P., Wasmus, Lise   +11 more
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Analysis of Nucleolar Protein Dynamics Reveals the Nuclear Degradation of Ribosomal Proteins [PDF]

, 2007
Background: The nucleolus is a subnuclear organelle in which rRNAs are transcribed, processed, and assembled with ribosomal proteins into ribosome subunits.
Lamond, Angus I., Lam, Yun Wah, Andersen, J.S., Mann, M., Lamond, Angus I, Andersen, Jens S., Andersen, J., Lamond, Angus I.; id_orcid, Lamond, A.I., Mann, Matthias, Lam, Y.W., Lamond, A., Andersen, Jens S; id_orcid, Lam, Y.   +13 more
core   +1 more source