Results 11 to 20 of about 1,849,171 (299)

Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1 [PDF]

, 2012
Loss of the tumor suppressor Pdcd4 was reported for various tumor entities and proposed as a prognostic marker in tumorigenesis. We previously characterized decreased Pdcd4 protein stability in response to mitogenic stimuli, which resulted from p70S6K1 ...
Bajer, Magdalena M., Blees, Johanna, Bokesch, Heidi R., Brüne, Bernhard, Colburn, Nancy H., Gustafson, Kirk R., Henrich, Curtis J., McMahon, James B., Milke, Larissa, Rübsamen, Daniela, Schmid, Tobias, Schulz, Kathrin   +11 more
core   +6 more sources

Hyperglycemia triggers HIPK2 protein degradation [PDF]

, 2016
Homeodomain interacting protein kinase-2 (HIPK2) is an evolutionary conserved kinase that modulates several key molecular pathways to restrain tumor growth and induce p53-depending apoptotic cell-death in response to anticancer therapies. HIPK2 silencing
Baldari, Silvia, Cirone, Mara, Cuomo, Laura, D'Orazi, Gabriella, Garufi, Alessia, Granato, Marisa, Pistritto, Giuseppa   +6 more
core   +2 more sources

Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. [PDF]

, 2016
Mutations in human CLC-1 chloride channel are associated with the skeletal muscle disorder myotonia congenita. The disease-causing mutant A531V manifests enhanced proteasomal degradation of CLC-1.
Chen, Shu-Ching, Chen, Tsung-Yu, Hsieh, Hsin-Ying, Huang, Jing-Jia, Peng, Yi-Jheng, Tang, Chih-Yung, Wu, Chia-Ying, Wu, Hao-Han   +7 more
core   +1 more source

Myocardial Dysfunction in an Animal Model of Cancer Cachexia [PDF]

, 2011
Aims Fatigue is a common occurrence in cancer patients regardless of tumor type or anti-tumor therapies and is an especially problematic symptom in persons with incurable tumor disease.
Crawford, Danielle, Hutchinson, Kirk R., Lucchesi, Pamela A., McCarthy, Donna O., Velten, Markus, Wold, Loren E., Xu, Hui, Youtz, Dane J.   +7 more
core   +2 more sources

Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics [PDF]

, 2009
We revisit the dynamics of a gene repressed by its own protein in the case where the transcription rate does not adapt instantaneously to protein concentration but is a dynamical variable.
A. Goldbeter, Benjamin Parent, C. P. Fall, Constant Vandermoëre, François Lemaire, I. S. Gradshteyn, Marc Lefranc, Pierre-Emmanuel Morant, Quentin Thommen   +8 more
core   +7 more sources

Platinum-containing compound platinum pyrithione suppresses ovarian tumor proliferation through proteasome inhibition

Journal of Experimental & Clinical Cancer Research, 2017
Background Ovarian carcinoma is one of the most aggressive gynecological malignant neoplasms and makes up 25–30% of all cancer cases of the female genital tract.
Hongbiao Huang, Ni Liu, Yuning Liao, Ningning Liu, Jianyu Cai, Xiaohong Xia, Zhiqiang Guo, Yanling Li, Qirong Wen, Qi Yin, Yan Liu, Qingxia Wu, Dhivya Rajakumar, Xiujie Sheng, Jinbao Liu   +14 more
doaj   +1 more source

Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells. [PDF]

, 2013
DNA-dependent protein kinase (DNA-PK) has an important role in the repair of DNA damage and regulates the radiation sensitivity of glioblastoma cells. The VCP (valosine-containing protein), a chaperone protein that regulates ubiquitin-dependent protein ...
Cao, L, Fei, X, Jiang, N, Kong, X, Larner, J, Mi, J, Qiu, Y, Shen, Y, Sheng, K, Sun, P   +9 more
core   +1 more source

Regulation of Protein Degradation [PDF]

The Plant Cell, 1995
of understanding of how to preserve in vivo proteolytic activities in vitro also has interfered with the identification, purification, and analyses of proteinases. Although studies using heterologous proteins or synthetic peptide substrates will continue to provide valuable information, such studies must at some point utilize in vivo substrates if the ...
openaire   +2 more sources

Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes [PDF]

, 2018
Summary: Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress and
Allard, Camille, Alvarez-Mercado, Ana I, Arvan, Peter, Coons, Laurel A, Floyd, Z. Elizabeth, Fuselier, Taylor, Hewitt, Sylvia C, Kim, Jun Ho, Korach, Kenneth S, Levin, Ellis R, Mauvais-Jarvis, Franck, Urano, Fumihiko, Xu, Beibei   +12 more
core   +2 more sources

UPRmt and coordinated UPRER in type 2 diabetes

Frontiers in Cell and Developmental Biology, 2022
The mitochondrial unfolded protein response (UPRmt) is a molecular mechanism that maintains mitochondrial proteostasis under stress and is closely related to various metabolic diseases, such as type 2 diabetes (T2D).
Zhanfang Kang, Feng Chen, Wanhui Wu, Rui Liu, Tianda Chen, Fang Xu, Fang Xu   +6 more
doaj   +1 more source