Results 11 to 20 of about 1,148,268 (263)

Platinum-containing compound platinum pyrithione suppresses ovarian tumor proliferation through proteasome inhibition

Journal of Experimental & Clinical Cancer Research, 2017
Background Ovarian carcinoma is one of the most aggressive gynecological malignant neoplasms and makes up 25–30% of all cancer cases of the female genital tract.
Hongbiao Huang, Ni Liu, Yuning Liao, Ningning Liu, Jianyu Cai, Xiaohong Xia, Zhiqiang Guo, Yanling Li, Qirong Wen, Qi Yin, Yan Liu, Qingxia Wu, Dhivya Rajakumar, Xiujie Sheng, Jinbao Liu   +14 more
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Development of an oncogenic dedifferentiation SOX signature with prognostic significance in hepatocellular carcinoma

BMC Cancer, 2019
Background Gradual loss of terminal differentiation markers and gain of stem cell-like properties is a major hall mark of cancer malignant progression.
Mei-Mei Li, Yun-Qiang Tang, Yuan-Feng Gong, Wei Cheng, Hao-Long Li, Fan-En Kong, Wen-Jie Zhu, Shan-Shan Liu, Li Huang, Xin-Yuan Guan, Ning-Fang Ma, Ming Liu   +11 more
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UPRmt and coordinated UPRER in type 2 diabetes

Frontiers in Cell and Developmental Biology, 2022
The mitochondrial unfolded protein response (UPRmt) is a molecular mechanism that maintains mitochondrial proteostasis under stress and is closely related to various metabolic diseases, such as type 2 diabetes (T2D).
Zhanfang Kang, Feng Chen, Wanhui Wu, Rui Liu, Tianda Chen, Fang Xu, Fang Xu   +6 more
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Circular RNA circIKBKB promotes breast cancer bone metastasis through sustaining NF-κB/bone remodeling factors signaling

Molecular Cancer, 2021
Background Breast cancer (BC) has a marked tendency to spread to the bone, resulting in significant skeletal complications and mortality. Recently, circular RNAs (circRNAs) have been reported to contribute to cancer initiation and progression.
Yingru Xu, Shuxia Zhang, Xinyi Liao, Man Li, Suwen Chen, Xincheng Li, Xingui Wu, Meisongzhu Yang, Miaoling Tang, Yameng Hu, Ziwen Li, Ruyuan Yu, Mudan Huang, Libing Song, Jun Li   +14 more
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Regulation of Protein Degradation [PDF]

The Plant Cell, 1995
of understanding of how to preserve in vivo proteolytic activities in vitro also has interfered with the identification, purification, and analyses of proteinases. Although studies using heterologous proteins or synthetic peptide substrates will continue to provide valuable information, such studies must at some point utilize in vivo substrates if the ...
openaire   +2 more sources

A new gold(I) complex-Au(PPh3)PT is a deubiquitinase inhibitor and inhibits tumor growthResearch in context

EBioMedicine, 2019
Background: Ubiquitin-proteasome system (UPS) is integral to cell survival by maintaining protein homeostasis, and its dysfunction has been linked to cancer and several other human diseases.
Xiaofen Li, Qingtian Huang, Huidan Long, Peiquan Zhang, Huabo Su, Jinbao Liu   +5 more
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NUPR1 is a critical repressor of ferroptosis

Nature Communications, 2021
Ferroptosis is a type of iron-dependent regulated cell death, representing an emerging disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis, although the key regulator for ferroptosis in iron metabolism remains elusive ...
Jiao Liu, Xinxin Song, Feimei Kuang, Qiuhong Zhang, Yangchun Xie, Rui Kang, Guido Kroemer, Daolin Tang   +7 more
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An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis

Nature Communications, 2020
The involvement of long non-coding RNA (lncRNA) in the regulation of N6-methyladenosine (m6A) modification of RNA is unclear. Here, the authors show that LINC00266-1 encodes a peptide that binds to m6A reader, IGF2BP1 to enhance the recognition of m6A ...
Song Zhu, Ji-Zhong Wang, De Chen, Yu-Tian He, Nan Meng, Min Chen, Rui-Xun Lu, Xin-Hui Chen, Xiao-Lan Zhang, Guang-Rong Yan   +9 more
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XBP1‐elicited environment by chemotherapy potentiates repopulation of tongue cancer cells by enhancing miR‐22/lncRNA/KAT6B‐dependent NF‐κB signalling

Clinical and Translational Medicine, 2023
Background Tumour repopulation initiated by residual tumour cells in response to cytotoxic therapy has been described clinically and biologically, but the mechanisms are unclear.
Xiaoting Jia, Ge Wang, Lihong Wu, Hao Pan, Li Ling, Jianlei Zhang, Qingquan Wen, Jie Cui, Zhimin He, Bin Qi, Shuxu Zhang, Liyun Luo, Guopei Zheng   +12 more
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Peptides/Proteins Encoded by Non-coding RNA: A Novel Resource Bank for Drug Targets and Biomarkers

Frontiers in Pharmacology, 2018
Non-coding RNAs (ncRNAs) are defined as RNA molecules that do not encode proteins, but recent evidence has proven that peptides/proteins encoded by ncRNAs do indeed exist and usually contain less than 100 amino acids.
Song Zhu, Song Zhu, Jizhong Wang, Jizhong Wang, Yutian He, Yutian He, Nan Meng, Nan Meng, Guang-Rong Yan, Guang-Rong Yan   +9 more
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