Results 91 to 100 of about 284,480 (260)

Inactivation and spike protein denaturation of novel coronavirus variants by Cu_xO/TiO₂ nano-photocatalysts. [PDF]

Sci Rep, 2023
Tatsuma T, Nakakido M, Ichinohe T, Kuroiwa Y, Tomioka K, Liu C, Miyamae N, Onuki T, Tsumoto K, Hashimoto K, Wakihara T.   +10 more
europepmc   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Effect of enzymatic hydrolysates from sea cucumber ovum protein on fish storage quality and antifreeze activity

Food Science of Animal Products
Protein denaturation induced by ice crystal formation is the main contributor to the deterioration of fish quality during frozen storage. This study aims to extract hydrolysates capable of inhibiting protein denaturation from sea cucumber ovum protein ...
Zhe Xu, Shuang Guan, Zijin Qin, Xu Yan, Yikun Xu, Xiufang Dong, Yue Yu, Tingting Li   +7 more
doaj   +1 more source

Monitoring Protein Denaturation of Egg White Using Passive Microwave Radiometry (MWR). [PDF]

Diagnostics (Basel), 2022
Goryanin I, Ovchinnikov L, Vesnin S, Ivanov Y.   +3 more
europepmc   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Exploring Echinops polyceras Boiss. from Jordan: Essential Oil Composition, COX, Protein Denaturation Inhibitory Power and Antimicrobial Activity of the Alcoholic Extract. [PDF]

Molecules, 2023
Hasan HS, Shakya AK, Al-Jaber HI, Abu-Sal HE, Barhoumi LM.   +4 more
europepmc   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Improved heat stability of goat milk through adjustment of salt balance

Applied Food Research
Heat treatment induces the denaturation of proteins in goat milk, increasing its susceptibility to age gelation and precipitation during shelf life.
Jinyu Xu, Yumeng Zhang, Yinping Guo, Xiaoyang Pang, Lu Liu, Jinghua Yu, Hongjuan Li, Jiaping Lv, Shuwen Zhang   +8 more
doaj   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

The denaturation of proteins [PDF]

Biochemical Journal, 1932
Wilfrid James Loughlin, William Cudmore McCullagh Lewis   +1 more
openaire   +3 more sources