Results 111 to 120 of about 295,099 (303)

In Situ Observation of Chemically Induced Protein Denaturation at Solvated Interfaces. [PDF]

ACS Appl Mater Interfaces, 2023
Nirmalraj PN, Rossell MD, Dachraoui W, Thompson D, Mayer M.   +4 more
europepmc   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Urea-Mediated Protein Denaturation: A Consensus View

, 2016
We have performed all-atom molecular dynamics simulations of three structurally similar small globular proteins in 8 M urea and compared the results with pure aqueous simulations.
Chaitali Mukhopadhyay (319664), Atanu Das (1527556)   +1 more
core   +1 more source

THE INFLUENCE OF MINERALS AND LACTOSE CONTENT ON THE STABILITY OF WHEY PROTEIN POWDERS

Studia Universitatis Babes-Bolyai Chemia, 2017
The aim of this paper was to determine the minerals and lactose from a Zonar lactoserum concentrate (L-ZS) obtained by lyophilization as compared to other two commercial powders: a bio whey concentrate (BWP) and a whey protein isolate (IWP), in order to
Doina PRODAN, Miuța FILIP, Ioana PERHAIȚĂ, Mihaela VLASSA, Violeta POPESCU, Ioan MARCUS, Marioara MOLDOVAN   +6 more
doaj   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Evaluation of protein surface roughness index using its heat denatured aggregates

, 2009
Recent research works on potential of different protein surface describing parameters to predict protein surface properties gained significance for its possible implication in extracting clues on protein's functional site. In this direction, Surface
Tapobrata Lahiri, Hrishikesh Mishra
core  

Protein Denaturation and the Denatured State

, 2005
Protein denaturation experiments are routinely used to determine protein stability and to elucidate structural and dynamic effects of mutations, cofactors and ligands.
Bengt‐Harald Jonsson, Per Hammarström, Jonsson, Bengt-Harald,, Hammarström, Per,   +3 more
core   +1 more source

In-Vial Detection of Protein Denaturation Using Intrinsic Fluorescence Anisotropy. [PDF]

Anal Chem, 2023
Chullipalliyalil K, Elkassas K, McAuliffe MAP, Vucen S, Crean A.   +4 more
europepmc   +1 more source

The Denaturation of Staphylococcal Proteins [PDF]

Journal of Bacteriology, 1935
A P, Krueger, V C, Nichols
openaire   +2 more sources

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source