Results 11 to 20 of about 16,987,595 (305)
Consistency principle for protein design
Biophysics and Physicobiology, 2019 Protein design holds promise for applications such as the control of cells, therapeutics, new enzymes and protein-based materials. Recently, there has been progress in rational design of protein molecules, and a lot of attempts have been made to create ...
Rie Koga, Nobuyasu Koga
doaj +5 more sources
Protein design and RNA design: Perspectives. [PDF]
Quant BiolAbstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint ...
Chen X, Dai X, Lu P.
europepmc +4 more sources
Computational approaches for drug design at the Protein-Protein interface [PDF]
, 2010 The ability to design drugs that disrupt formation of protein-protein interfaces is of particular interest to the pharmaceutical industry due to its promise for opening an entire new range of drug targets, many of which have already been well ...
Fuller, Jonathan Christopher
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Designing repeat proteins: a modular approach to protein design [PDF]
Current Opinion in Structural Biology, 2017 Repeat proteins present unique opportunities for engineering because of their modular nature that potentially allows LEGO® like construction of macromolecules. Nature takes advantage of these properties and uses this type of scaffold for recognition, structure, and even signaling purposes.
Parmeggiani, Fabio, Huang, Po-Ssu
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Protein-Ligand Interactions and Drug Design
, 2021 This detailed book collects modern and established computer-based methods aimed at addressing the drug discovery challenge from disparate perspectives by exploiting information on ligand-protein recognition.
Ballante, Flavio,
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Protein design automation [PDF]
Protein Science, 1996 AbstractWe have conceived and implemented a cyclical protein design strategy that couples theory, computation, and experimental testing. The combinatorially large number of possible sequences and the incomplete understanding of the factors that control protein structure are the primary obstacles in protein design.
Dahiyat, Bassil I., Mayo, Stephen L.
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Biochemical Society Transactions, 2013 Protein engineering is at an exciting stage because designed protein–protein interactions are being used in many applications. For instance, three designed proteins are now in clinical trials. Although there have been many successes over the last decade, protein engineering still faces numerous challenges.
Nicholas, Sawyer +2 more
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Computational Protein Design Force Field Optimization: A Negative Design Approach [PDF]
, 2007 An accurate force field is essential to computational protein design and protein folding studies. Proper force field tuning is problematic, however, due in part to the incomplete modeling of the unfolded state.
Alvizo, Oscar
core +1 more source
Structure-based design of stabilized recombinant influenza neuraminidase tetramers
Nature Communications, 2022 Influenza virus neuraminidase (NA) is a drug target and a potential vaccine antigen. Here, the authors provide a detailed analysis of the conformational stability of NA, and show how expression and stability of recombinant NA antigens can be strengthened
Daniel Ellis +21 more
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Consensus protein design [PDF]
Protein Engineering Design and Selection, 2016 A popular and successful strategy in semi-rational design of protein stability is the use of evolutionary information encapsulated in homologous protein sequences. Consensus design is based on the hypothesis that at a given position, the respective consensus amino acid contributes more than average to the stability of the protein than non-conserved ...
Porebski, Benjamin T., Buckle, Ashley M.
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