Results 41 to 50 of about 16,987,595 (305)
Statistical Models of the Protein Fitness Landscape: Applications to Protein Evolution and Engineering [PDF]
, 2012 Understanding the protein fitness landscape is important for describing how natural proteins evolve and for engineering new proteins with useful properties.
Romero, Philip Anthony
core +1 more source
Frontiers in Bioengineering and Biotechnology, 2021 The conversion of Kraft lignin in plant biomass into renewable chemicals, aiming at harvesting aromatic compounds, is a challenge process in biorefinery.
Wen-Jie Guo +7 more
doaj +1 more source
Non-Contiguous Protein Recombination [PDF]
, 2013 Swapping sequence elements among related proteins can produce chimeric proteins with novel behaviors and improved properties such as enhanced stability. Although homologous mutations are much more conservative than random mutations, chimeras of distantly-
Smith, Matthew Alexander
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Machine Learning on a Robotic Platform for the Design of Polymer-Protein Hybrids [PDF]
, 2022 Polymer-protein hybrids are intriguing materials that can bolster protein stability in non-native environments, thereby enhancing their utility in diverse medicinal, commercial, and industrial applications.
Heloise, Mugnier +8 more
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Complex network analysis of thermostable mutants of Bacillus subtilis Lipase A
Applied Network Science, 2017 Three-dimensional structures of proteins that regulate their functions can be modelled using complex network based approaches for understanding the structure-function relationship.
Nitika Kandhari, Somdatta Sinha
doaj +1 more source
mAbs, 2020 Antibody variable domains contain “complementarity-determining regions” (CDRs), the loops that form the antigen binding site. CDRs1-3 are recognized as the canonical CDRs.
Simon P. Kelow +2 more
doaj +1 more source
Origin of the designability of protein structures [PDF]
Physical Review E, 1999 17 pages, 2 ...
Tatsumi, Rie, Chikenji, George
openaire +3 more sources
Digital Tools for Collaborative Design Processes [PDF]
, 2021 Diverse practices of collaboration in design, research, teaching, or academia increasingly rely on digital online tools to facilitate processes of working and creating together. But a lot of the available digital platforms are not necessarily designed
Ibach, Merle, Greiner-Petter, Moritz
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De novo design of a macrocycle-induced dimerization system for cellular control
Nature CommunicationsInvestigating and manipulating cellular events requires precise control of protein function. To enable control over cellular processes, we set out to design a chemically induced dimerization (CID) system consisting of a de novo-designed ligand and ...
Stephanie Hanna +14 more
doaj +1 more source
Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin +17 more
wiley +1 more source