Results 21 to 30 of about 16,987,595 (305)
Exploring the design applications of key emerging materials from natural sciences through a design ideation workshop [PDF]
, 2023 10th Congress of the International Association of Societies of Design Research (IASDR 2023) 9-13 October 2023, Milan, Italy202405 bcchVersion of ...
Wang, X +15 more
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Translational Neurodegeneration, 2021 Background Amyloid-β (Aβ) immunotherapy is a promising therapeutic strategy in the fight against Alzheimer’s disease (AD). A number of monoclonal antibodies have entered clinical trials for AD. Some of them have failed due to the lack of efficacy or side-
Fadi Rofo +10 more
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Computational protein design [PDF]
Structure, 1999 A 'protein design cycle', involving cycling between theory and experiment, has led to recent advances in rational protein design. A reductionist approach, in which protein positions are classified by their local environments, has aided development of an appropriate energy expression. The computational principles and practicalities of the protein design
Street, Arthur G., Mayo, Stephen L.
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Development and Validation of Optimization Methods for the Design of Protein Sequences and Combinatorial Libraries [PDF]
, 2009 To facilitate the design of protein sequences with desired properties, simulation techniques have been developed to allow large portions of amino acid sequence space to be evaluated by computer.
Allen, Benjamin Daniel
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De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8
Nature Communications, 2023 The RGD (Arg-Gly-Asp)-binding integrins αvβ6 and αvβ8 are clinically validated cancer and fibrosis targets of considerable therapeutic importance.
Anindya Roy +39 more
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Frontiers in Immunology, 2021 The unprecedented global demand for SARS-CoV-2 vaccines has demonstrated the need for highly effective vaccine candidates that are thermostable and amenable to large-scale manufacturing. Nanoparticle immunogens presenting the receptor-binding domain (RBD)
Daniel Ellis +52 more
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Protein-Ligand Interactions: Docking, Design and Conformation Change [PDF]
, 2003 Virtual ligand screening has proven to be a successful strategy in drug design. An in house-developed procedure (HierDock), a coarse grain docking method followed by a fine grain search procedure, was used to determine the binding site for sugars in the
Datta, Deepshikha
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Mohammad-Khatami/grover-protein-desing: Gate-based Quantum Computing for Protein Design
, 2022 The initial release of quantum approaches for protein design using Grover's ...
Mohammad Khatami
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Applications of Computational Protein Design [PDF]
, 2006 Computational protein design determines the amino acid sequence(s) that will adopt a desired fold. It allows the sampling of a large sequence space in a short amount of time compared to experimental methods.
Mao, Jessica
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Computational Design and Experimental Characterization of Protein Oligomers [PDF]
, 2004 Previous efforts in designing protein binding interfaces have focused on altering binding specificities. These methods fall short, however, when applied to the design of novel binding sites due to difficulties in accurately modeling protein backbones ...
Huang, Po-Ssu
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